SEMANTIC MEMORY IMPAIRMENT IN ALZHEIMERS-DISEASE - FAILURE OF ACCESS OR DEGRADED KNOWLEDGE
SEMANTIC MEMORY IMPAIRMENT IN ALZHEIMERS-DISEASE - FAILURE OF ACCESS OR DEGRADED KNOWLEDGE
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DOI：
10.1016/0028-3932(92)90104-t
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发表时间：
1992-04-01
期刊：
影响因子：
2.6
通讯作者：
BUTTERS, N
中科院分区：
文献类型：
--
作者：
HODGES, JR;SALMON, DP;BUTTERS, N
一组神经心理学测试旨在评估语义知识相同的项目内和跨不同的方式进行了管理，一组22例阿尔茨海默型痴呆症（DAT）和26个匹配的控制。DAT患者在类别流畅性、图片命名、口语单词图片匹配、图片分类和产生口头定义的测试中受损。排序和定义测试的上位知识的相对保存，以及不成比例的减少，从较低的顺序类别的范例的生成。对每个患者在不同测试中所犯错误的分析显示，各个项目之间存在显著的对应关系。这些研究结果提供了令人信服的证据表明，DAT的语义故障是由存储退化引起的。
A battery of neuropsychological tests designed to assess semantic knowledge about the same items both within and across different modalities was administered to a group of 22 patients with dementia of the Alzheimer type (DAT) and 26 matched controls. The DAT patients were impaired on tests of category fluency, picture naming, spoken word-picture matching, picture sorting and generation of verbal definitions. A relative preservation of superordinate knowledge on the sorting and definition tests, as well as a disproportionate reduction in the generation of exemplars from lower order categories was noted. Analysis of the errors made by each patient across the different tests, revealed a significant correspondence between the individual items. These findings offer compelling evidence that the semantic breakdown in DAT is caused by storage degradation.