Cutting edge: Gut microenvironment promotes differentiation of a unique memory CD8 T cell population
Cutting edge: Gut microenvironment promotes differentiation of a unique memory CD8 T cell population
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DOI：
10.4049/jimmunol.176.4.2079
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发表时间：
2006-02-15
影响因子：
4.4
通讯作者：
Ahmed, R
中科院分区：
文献类型：
--
作者：
Masopust, D;Vezys, V;Ahmed, R
组织微环境是否影响记忆性CD8 T细胞分化尚不清楚。我们证明，肠道中的病毒特异性上皮内淋巴细胞既不像从脾脏或血液中分离的中央也不像效应记忆CD8 T细胞。这种独特的表型在肠道内原位产生，表明解剖位置在记忆分化程序中起诱导作用。为了支持这一假设，记忆性CD8 T细胞在位置改变时改变表型。在转移和体内再刺激后，肠或脾记忆细胞增殖，散布到脾和肠中，并采用其新环境的记忆T细胞表型特征。我们的数据表明，解剖位置直接影响记忆T细胞分化程序。
Whether tissue microenvironment influences memory CD8 T cell differentiation is unclear. We demonstrate that virus-specific intraepithelial lymphocytes in gut resemble neither central nor effector memory CD8 T cells isolated from spleen or blood. This unique phenotype arises in situ within the gut, suggesting that anatomic location plays an inductive role in the memory differentiation program. In support of this hypothesis, memory CD8 T cells changed phenotype upon change in location. After transfer and in vivo restimulation, gut or spleen memory cells proliferated, disseminated into spleen and gut, and adopted the memory T cell phenotype characteristic of their new environment. Our data suggests that anatomic location directly impacts the memory T cell differentiation program.