Circadian changes in Drosophila motor terminals
Circadian changes in Drosophila motor terminals
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DOI：
10.1002/dneu.20332
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发表时间：
2007-03-01
影响因子：
3
通讯作者：
Cantera, Rafael
中科院分区：
文献类型：
--
作者：
Mehnert, Kerstin I.;Beramendi, Ana;Cantera, Rafael
在果蝇身上，就像在大多数其他高等生物中一样，生物钟控制着休息/睡眠和运动活动的节奏分布。在这里，我们报道了果蝇飞行神经肌肉终末的形态在昼夜之间的变化，突触大小的节律在恒定的黑暗中持续，但随着年龄的增长而消失。此外，时钟基因永恒和周期的心律失常突变也扰乱了这种昼夜节律。最后，这些时钟突变体对神经元分枝的非节律表型也有相反的影响，Tim突变体表现出戏剧性的超分枝形态，PER突变体的分枝比野生型果蝇少。这些意想不到的结果进一步揭示了这些经典行为突变的昼夜节律和非时钟相关的多效性效应。(C)2007年威利期刊公司。
in Drosophila melanogaster, as in most other higher organisms, a circadian clock controls the rhythmic distribution of rest/sleep and locomotor activity. Here we report that the morphology of Drosophila flight neuromuscular terminals changes between day and night, with a rhythm in synaptic bouton size that continues in constant darkness, but is abolished during aging. Furthermore, arrhythmic mutations in the clock genes timeless and period also disrupt this circadian rhythm. Finally, these clock mutants also have an opposing effect on the nonrhythmic phenotype of neuronal branching, with tim mutants showing a dramatic hyperbranching morphology and per mutants having fewer branches than wild-type flies. These unexpected results reveal further circadian as well as nonclock related pleiotropic effects for these classic behavioral mutants. (c) 2007 Wiley Periodicals, Inc.