ADHESION BETWEEN EPITHELIAL-CELLS AND T-LYMPHOCYTES MEDIATED BY E-CADHERIN AND THE ALPHA(E)BETA(7) INTEGRIN
ADHESION BETWEEN EPITHELIAL-CELLS AND T-LYMPHOCYTES MEDIATED BY E-CADHERIN AND THE ALPHA(E)BETA(7) INTEGRIN
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DOI：
10.1038/372190a0
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发表时间：
1994-11-10
期刊：
影响因子：
64.8
通讯作者：
BRENNER, MB
中科院分区：
文献类型：
--
作者：
CEPEK, KL;SHAW, SK;BRENNER, MB
与无根细胞类型不同，淋巴细胞通过脉管系统迁移，弥漫性分布在组织中或组织在淋巴样结构中。包括选择素、整合素及其对抗受体在内的一系列复杂的粘附分子介导淋巴细胞归巢和向组织迁移，并可能组成性地表达或诱导（1,2）。然而，介导淋巴细胞在实质内组织特异性滞留的分子尚未被确定。沿肠细胞底外侧的上皮可见肠上皮内淋巴细胞。这些粘膜免疫系统的T细胞作为淋巴细胞组织特异性区隔化的模型。我们研究了这些肠上皮内淋巴细胞的定位是否可以通过选择性表达在该T细胞亚群上的粘附分子和上皮细胞上的组织限制性粘附分子之间的特异性相互作用来介导。本研究表明，上皮细胞和上皮内淋巴细胞之间的异型粘附相互作用是由E-钙粘蛋白和α (E) β(7)整合素介导的。
IN contrast to sessile cell types, lymphocytes migrate through the vasculature to become diffusely distributed in tissues or organized in lymphoid structures. A complex array of adhesion molecules including selectins, integrins and their counter-receptors mediate lymphocyte homing and migration into tissues and may be constitutively expressed or induced(1,2). However, the molecules that mediate the tissue-specific retention of lymphocytes within the parenchyma have not been identified. Along the epithelium at the basolateral surface of enterocytes, intestinal intraepithelial lymphocytes are found. These T cells of the mucosal immune system serve as a model for the tissue-specific compartmentalization of lymphocytes. We investigated whether the localization of these intestinal intraepithelial lymphocytes could be mediated by specific interactions between adhesion molecules expressed selectively on this subpopulation of T cells and tissue-restricted adhesion molecules on epithelial cells. Here we show that heterotypic adhesive interactions between epithelial cells and intraepithelial lymphocytes in vitro are mediated by E-cadherin and the alpha(E) beta(7) integrin.