Living donor liver transplantation: looking back at my 30years of experience
Living donor liver transplantation: looking back at my 30years of experience
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DOI：
10.1007/s00595-018-1744-6
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发表时间：
2019-04-01
期刊：
影响因子：
2.5
通讯作者：
Makuuchi, Masatoshi
中科院分区：
文献类型：
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作者：
Makuuchi, Masatoshi
自从我从国立癌症中心搬到信州大学以来，我一直在进行活体肝脏移植（LDLT），这是挽救终末期肝病患者生命的唯一途径。1990年6月，我们进行了第一例LDLT，这是日本第一例成功的病例。移植手术28年后，病人仍然健康，享受着正常的生活。1993年，我们成功进行了成人对成人LDLT，这是世界上第一例成功的病例。病人过了17年的正常生活，直到70岁去世。对于小孩子来说，成年捐赠者的左肝太大，无法闭合腹部。然而，在青少年或成人中，即使使用整个右肝，移植物的体积也太小。标准肝脏体积（SLV）的概念已被证明对该程序非常重要，其计算方法如下：706.2 ×体表面积+2.4。我们提出了一种评价肝脏充血的多普勒超声方法。此外，我们设计了右外侧部移植物。多年来，我们在许多方面为LDLT做出了贡献，并发表了许多论文。我们认为我们的发现不仅对LDLT很有用，而且对其他肝切除术也很有用。
Since I moved from the National Cancer Center to Shinshu University, I have been performing living donor liver transplantation (LDLT), which is the only way to save the life of patients with end-stage liver disease. In June 1990, we performed the first LDLT that case was the first successful case in Japan. The patient remains healthy and is enjoying a normal life still 28years after the transplant. In 1993, we successfully performed adult-to-adult LDLT, which was the first successful case in the world. The patient enjoyed a normal life for 17years until she died at 70years of age. For small children, the left liver of adult donors is too large to close the abdomen. However, in adolescents or adults, even when the whole right liver is used, the volume of the graft is too small. The concept of the standard liver volume (SLV) has proven very important for this procedure and is calculated as follows: 706.2xbody surface area+2.4. We proposed a method for evaluating the congestion of the liver by Doppler ultrasound. In addition, we devised the right lateral sector graft. Over the years, we have contributed to LDLT in many ways and published many papers. We feel that our findings are quite useful not only for LDLT but also for other hepatectomy procedures.