Neuronal metabolism governs cortical network response state
Neuronal metabolism governs cortical network response state
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DOI：
10.1073/pnas.0600604103
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发表时间：
2006-04-04
影响因子：
11.1
通讯作者：
Whittington, MA
中科院分区：
文献类型：
--
作者：
Cunningham, MO;Pervouchine, DD;Whittington, MA
哺乳动物的觉醒水平与新陈代谢状态和皮层神经元反应的特定模式有关。特别是，高活动期(上升阶段)和低活动期(下降阶段)之间的节律转换在清醒和深度睡眠/麻醉之间有所不同。目前关于睡眠和清醒之间皮质反应状态变化的观点分为神经网络介导的机制和神经元代谢相关的机制。在这里，我们证明了网络状态的慢振荡是这两种机制相互作用的结果。具体地说，兴奋性神经元的递归网络，其膜电位部分由ATP调节的钾(K-ATP)通道控制，通过涉及缓慢的红藻氨酸受体介导的事件的兴奋网络活动与由此激活的依赖于ATP的稳态机制之间的相互作用来调节反应状态振荡。这些发现表明，K-ATP通道在哺乳动物大脑皮层的神经元代谢状态和网络反应性之间起着接口作用。
The level of arousal in mammals is correlated with metabolic state and specific patterns of cortical neuronal responsivity. In particular, rhythmic transitions between periods of high activity (up phases) and low activity (down phases) vary between wakefulness and deep sleep/anesthesia. Current opinion about changes in cortical response state between sleep and wakefulness is split between neuronal network-mediated mechanisms and neuronal metabolism-related mechanisms. Here, we demonstrate that slow oscillations in network state are a consequence of interactions between both mechanisms. Specifically, recurrent networks of excitatory neurons, whose membrane potential is partly governed by ATP-modulated potassium (K-ATP) channels, mediate response-state oscillations via the interaction between excitatory network activity involving slow, kainate receptor-mediated events and the resulting activation of ATP-dependent homeostatic mechanisms. These findings suggest that K-ATP channels function as an interface between neuronal metabolic state and network responsivity in mammalian cortex.