Association of interleukin-1α, 4, 6, TNF-α gene polymorphisms with Hashimoto′s thyroiditis
Association of interleukin-1α, 4, 6, TNF-α gene polymorphisms with Hashimoto′s thyroiditis
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发表时间：
2000
影响因子：
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通讯作者：
J. Ling;Gong Ying;Jiang Wei-yan;Q. Wei;Zhang Xiao-li;Wu Chuan-long
中科院分区：
文献类型：
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作者：
J. Ling;Gong Ying;Jiang Wei-yan;Q. Wei;Zhang Xiao-li;Wu Chuan-long
研究白细胞介素（IL）-1α、IL-4、IL-6、肿瘤坏死因子-α（TNF-α）基因多态性与中国山东地区人群桥本氏甲状腺炎（HT）的关系。结果表明，HT组IL-4启动子区-590位点t等位基因频率明显低于对照组HT组IL-4（-590）c/t杂合子基因型频率显著低于对照组（0.060vs0.155，P0.05 HT组IL-1α、IL-6、TNF-α基因多态性与对照组比较差异无统计学意义（P > 0. 05）。
The association of the polymorphisms of interleukin (IL)-1α, IL-4, IL-6, tumor necrosis factor-α (TNF-α) gene with Hashimoto′s thyroiditis (HT) in Shandong population of China was investigated. The results showed that the frequency of the t allele in the promoter region of IL-4 at position -590 in HT group was significantly lower than that in control group (0.060 vs 0.155, P0.05), the frequency of IL-4 (-590) c/t heterozygote genotype in HT group was significantly lower than that in control group (0.100 vs 0.250, P0.05), and there were no significant differences between HT group and control group for IL-1α, IL-6, TNF-α gene polymorphisms.