Bladder function in patients with dystonia undergoing deep brain stimulation
Bladder function in patients with dystonia undergoing deep brain stimulation
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DOI：
10.1016/j.parkreldis.2014.05.016
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发表时间：
2014-09-01
影响因子：
4.1
通讯作者：
Kaelin-Lang, Alain
中科院分区：
文献类型：
--
作者：
Mordasini, Livio;Kessler, Thomas M.;Kaelin-Lang, Alain
Introduction: Neurogenic bladder dysfunction is well described in Parkinson's disease and has a major impact on quality of live. In contrast, little is known about the extent of urinary symptoms in other movement disorders such as dystonia and about the role of the basal ganglia in bladder control..Patients and methods: A consecutive series of 11 patients with severe dystonia undergoing deep brain stimulation (DBS) of the globus pallidus internus was prospectively enrolled. Bladder function was assessed by the International Prostate Symptom Score and urodynamic investigation (UDI) before DBS surgery and afterwards in the conditions with and without DBS.Results: In UDI before DBS surgery, detrusor overactivity was found in 36% (4/11) of dystonia patients. With pallidal DBS ON, maximum flow rate significantly decreased, post-void residual significantly increased and detrusor overactivity disappeared..Conclusions: Pathological urodynamic changes can be found in a relevant percentage of dystonia patients. Pallidal DBS has a relaxing effect on detrusor function indicating a role of the basal ganglia in lower urinary tract control. Thus, a better understanding on how subcortical networks influence lower urinary tract function might open new therapeutic perspectives.. (C) 2014 Elsevier Ltd. All rights reserved.
