Design and synthesis of novel inhibitors of gelatinase B.
Design and synthesis of novel inhibitors of gelatinase B.
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新型明胶酶B抑制剂的设计与合成。
DOI：
10.1016/s0960-894x(02)00365-7
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发表时间：
2002
影响因子：
2.7
通讯作者：
Ellman,JonathanA
中科院分区：
文献类型：
--
作者：
Wang,Xueqing;Choe,Youngchool;Craik,CharlesS;Ellman,JonathanA
开发了一种新的方法来鉴定具有新的锌结合基团的非肽类金属蛋白酶抑制剂。将该方法应用于基质金属蛋白酶-9，鉴定出氨基甲基苯并咪唑类似物7a，IC 50 =13 μM。
A new method was developed to identify nonpeptidic metalloproteinase inhibitors with novel zinc binding groups. Application of this method to matrix metalloproteinase-9 resulted in the identification of aminomethyl benzimidazole analogue 7a with an IC50=13 μM.