Cardiovascular responses produced by microinjection of serotonin-receptor agonists into the paraventricular nucleus in conscious rats.
Cardiovascular responses produced by microinjection of serotonin-receptor agonists into the paraventricular nucleus in conscious rats.
复制标题
将血清素受体激动剂显微注射到清醒大鼠的室旁核中产生的心血管反应。
DOI：
10.1097/00005344-199902000-00001
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发表时间：
1999
影响因子：
3
通讯作者：
Alper,RH
中科院分区：
文献类型：
--
作者：
Bell,AA;Butz,BL;Alper,RH
大脑中血清素（5-羟色胺，5-HT）受体的激活通过改变自主神经流出产生心血管反应。室旁核 (PVN) 含有中等密度的 5-HT 受体，并与自主神经中枢有联系。实验旨在确定向清醒大鼠的PVN施用5-HT 2-和5-HT 1A-受体激动剂是否会产生心血管反应。将 5-HT 2-受体激动剂 DOI [(±)-1-(2, 5-二甲氧基-4-碘苯基)-2-氨基丙烷 HCl] 显微注射到 PVN 中，会产生剂量依赖性（1-10 nmol）心率和血压增加；峰值响应分别为+ 39±10次/分钟和+ 6±2 mm Hg。同时向 PVN 施用选择性 5-HT 2 受体拮抗剂 LY53857 可以阻断这两种反应。相比之下，显微注射选择性5-HT 1A 受体激动剂R(+)-8-OH-DPAT [R(+)8-羟基-2-(二正丙氨基)四氢化萘HBr； 1-10 nmol]进入PVN不会影响血压或心率。这些数据表明从中缝核投射到PVN或PVN附近的5-HT神经元可以通过5-HT 2 受体参与心血管系统的中枢控制。显然，终止于 PVN 的 5-HT 神经元可以增加血压和心率，并产生交感肾上腺激活、代谢和激素反应，与在几种不同的应激范例中观察到的一致。
Activation of serotonin (5-hydroxytryptamine, 5-HT) receptors in the brain produces cardiovascular responses by altering autonomic outflow. The paraventricular nucleus (PVN) contains a modest density of 5-HT receptors and has connections to autonomic centers. Experiments were designed to determine whether cardiovascular responses were produced by the administration of 5-HT 2-and 5-HT 1A-receptor agonists into the PVN of conscious rats. The microinjection of the 5-HT 2-receptor agonist DOI [(±)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane HCl] into the PVN produced dose-dependent (1-10 nmol) increases in heart rate and blood pressure; the peak responses were+ 39±10 beats/min and+ 6±2 mm Hg, respectively. Both responses were blocked by the concomitant administration of the selective 5-HT 2-receptor antagonist LY53857 into the PVN. By contrast, the microinjection of the selective 5-HT 1A-receptor agonist R (+)-8-OH-DPAT [R (+) 8-hydroxy-2-(di-n-propylamino) tetralin HBr; 1-10 nmol] into the PVN did not affect blood pressure or heart rate. These data suggest that 5-HT neurons projecting from the raphé nuclei to or near the PVN can participate in the central control of the cardiovascular system by way of 5-HT 2 receptors. Apparently 5-HT neurons terminating in the PVN can increase blood pressure and heart rate and produce sympathoadrenal activation, metabolic and hormonal responses consistent with those observed in several different stress paradigms.