Decreased left posterior insular activity during auditory language in autism.
Decreased left posterior insular activity during auditory language in autism.
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DOI：
10.3174/ajnr.a1789
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发表时间：
2010-01
期刊：
影响因子：
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通讯作者：
Lainhart JE
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文献类型：
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作者：
Anderson JS;Lange N;Froehlich A;DuBray MB;Druzgal TJ;Froimowitz MP;Alexander AL;Bigler ED;Lainhart JE
自闭症谱系障碍患者通常表现出非典型的语言模式，包括言语起始延迟，言语字面解释以及言语中社会和情感线索的识别能力差。我们在听觉语言任务中获得了功能磁共振成像图像，以评估控制和高功能自闭症人群之间语言网络激活的系统差异。41名右利手男性受试者（26名高功能自闭症患者，15名对照）进行了研究，使用听觉短语识别任务，并确定了组间差异激活的区域。手的偏好，语言智商，年龄和语言功能测试作为协变量纳入分析。对照组和自闭症受试者表现出类似的语言激活网络，但有两个显着差异。与自闭症受试者相比，对照受试者的左后额叶激活显著增加（p<0.05，FDR），而自闭症受试者与对照受试者相比，接受性语言的双侧性增加。标准化测试中接受性语言得分越高，左侧韦尼克区后部的激活程度越高。较高的语言智商与双侧布罗卡区的激活程度以及前额叶皮层和外侧运动前皮层的参与程度有关。对照组受试者在接受性语言过程中表现出更大的后额叶激活，这可能与自闭症患者语言情感处理受损有关。自闭症受试者表现出更大的双边激活的接受性语言领域是不成比例的差异，在自闭症和对照人群的手偏好。
Individuals with autism spectrum disorders often exhibit atypical language patterns including delay of speech onset, literal speech interpretation, and poor recognition of social and emotional cues in speech. We acquired fMRI images during an auditory language task to evaluate for systematic differences in language network activation between control and high-functioning autistic populations. 41 right-handed male subjects (26 high-functioning autistic, 15 control) were studied using an auditory phrase recognition task, and areas of differential activation between groups were identified. Hand preference, verbal IQ, age, and language function testing were included as covariables in the analysis. Control and autistic subjects showed similar language activation networks, with two notable differences. Control subjects showed significantly increased activation in the left posterior insula compared to autistic subjects (p<0.05, FDR), and autistic subjects showed increased bilaterality of receptive language compared to control subjects. Higher receptive language score on standardized testing was associated with greater activation of the posterior aspect of left Wernicke’s area. Higher verbal IQ was associated with greater activation of bilateral Broca’s area and involvement of prefrontal cortex and lateral premotor cortex. Control subjects showed greater activation of the posterior insula during receptive language, which may correlate with impaired emotive processing of language in autism. Autism subjects showed greater bilateral activation of receptive language areas that was out of proportion to differences in hand preference in autism and control populations.