Cap-shaped gold nanoparticles for an optical biosensor
Cap-shaped gold nanoparticles for an optical biosensor
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DOI：
10.1016/s0925-4005(99)00393-7
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发表时间：
2000-04-20
影响因子：
8.4
通讯作者：
Takei, H
中科院分区：
文献类型：
--
作者：
Himmelhaus, M;Takei, H
通过在直径为110 nm的无规吸附单分散聚苯乙烯（PS）微球上蒸镀Au，制备了帽状Au纳米粒子。所得样品在可见光区具有100 nm的带宽，光密度的消光系数为2.4。消光峰的位置被发现线性依赖于环境的折射率。正如所证明的成功检测十八硫醇单层的形成以及生物素/抗生物素蛋白结合，亚单层的灵敏度，这里报道的简单的新设备有望开发廉价的光学生物传感器的大规模并行检测。(C)2000 Elsevier Science B. V.保留所有权利。
Cap-shaped Au nanoparticles have been formed by evaporating An on a dense monolayer of randomly adsorbed monodisperse polystyrene (PS) spheres with a diameter of 110 nm. The resulting sample exhibits a large extinction coefficient of optical density of 2.4 with a bandwidth of 100 nm in the visible region. The extinction peak position is found to depend linearly on the refractive index of the environment. As demonstrated by successful detection of octadecanethiolate monolayer formation as well as biotin/avidin binding, the sub-monolayer sensitivity of the simple novel device reported here promises development of inexpensive optical biosensors for massively parallel detection. (C) 2000 Elsevier Science B.V. All rights reserved.