EFFECT OF RESPIRATORY VIRUS-INFECTIONS INCLUDING RHINOVIRUS ON CLINICAL STATUS IN CYSTIC-FIBROSIS
EFFECT OF RESPIRATORY VIRUS-INFECTIONS INCLUDING RHINOVIRUS ON CLINICAL STATUS IN CYSTIC-FIBROSIS
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DOI：
10.1136/adc.73.2.117
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发表时间：
1995-08-01
影响因子：
5.2
通讯作者：
HEAF, DP
中科院分区：
文献类型：
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作者：
SMYTH, AR;SMYTH, RL;HEAF, DP
对108名囊性纤维化患者进行了一年多的调查，以确定鼻病毒或其他呼吸道病毒感染与临床状态之间是否存在关联。在研究开始和结束时记录第一秒用力呼气量(FEV(1))、用力肺活量(FVC)、Shwachman评分、Chrispin-Norman胸片评分和身高体重百分比；记录静脉注射抗生素的天数。在呼吸恶化期间，取鼻咽抽吸物进行病毒研究。在入选时和每次呼吸加重后2-6周收集血清。76名患者中有157人病情恶化。在44例急性加重期中检测到呼吸道病毒感染，16%(25/157)的加重期患者中存在鼻病毒。有一种或多种呼吸道病毒感染的患者与没有感染的患者进行了比较。当考虑到所有呼吸道病毒感染时，患者的Shwachman评分恶化程度明显更大，接受静脉注射抗生素的天数显著增加。当单独考虑鼻病毒时，患者接受静脉注射抗生素的天数显著增加，但临床状况没有恶化。然而，感染另一种呼吸道病毒的患者的FEV(1)显著下降，趋势是FVC和Shwachman评分显著下降。
One hundred and eight patients with cystic fibrosis were investigated over one year to determine whether an association existed between rhinovirus or other respiratory virus infection and clinical status. Forced expiratory volume in one second (FEV(1)), forced vital capacity (FVC), Shwachman score, Chrispin-Norman chest radiograph score, and percentage weight for height were recorded at the beginning and end of the study; days of intravenous antibiotics were noted. Nasopharyngeal aspirates were taken for viral studies during respiratory exacerbations. Serum was collected at enrolment and 2-6 weeks after each respiratory exacerbation. One hundred and fifty seven exacerbations occurred in 76 patients. Respiratory virus infection was detected in 44 exacerbations and rhinovirus was present in 16% (25/157) of exacerbations. Patients with one or more respiratory virus infections were compared with those who had none. When all respiratory virus infections were considered, patients had a significantly greater deterioration in Shwachman score and received significantly more days of intravenous antibiotics. When rhinovirus was considered separately, patients received significantly more days of intravenous antibiotics, but showed no deterioration in clinical status. However, patients infected with another respiratory virus had a significant decline in FEV(1), with trends towards significance for decline in FVC and Shwachman score.