High expression of Ras-specific guanine nucleotide-releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis.
High expression of Ras-specific guanine nucleotide-releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis.
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DOI：
10.1111/pin.13069
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发表时间：
2021-04
影响因子：
2.2
通讯作者：
Sakamoto N
中科院分区：
文献类型：
--
作者：
Nakagawa T;Kim Y;Kano J;Murata Y;Kosibaty Z;Noguchi M;Sakamoto N
采用免疫组织化学方法检测肺腺癌中Ras特异性鸟苷酸释放因子2（RasGRF 2）的表达与临床病理特征和预后的关系。与低表达相比，RasGRF 2高表达与不良预后更密切相关。有趣的是，磷酸化上皮细胞转化2（pECT 2）的表达，与RasGRF 2一样，也是一种鸟嘌呤核苷酸交换因子，也与预后相关，RasGRF 2和pECT 2高表达的患者的预后比两者均阴性的患者差得多。
The expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinomas was examined using immunohistochemistry in relation to clinicopathological characteristics and prognosis. In comparison to low expression, high expression of RasGRF2 was more closely associated with poor prognosis. Interestingly, expression of phosphorylated epithelial cell transforming 2 (pECT2), which – like RasGRF2 – is also a guanine‐nucleotide exchange factor, was also associated with prognosis, and patients with high expression of both RasGRF2 and pECT2 had a much poorer outcome than those who were negative for both.
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影响因子：
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作者：
Kosibaty, Zeinab;Murata, Yoshihiko;Noguchi, Masayuki
通讯作者：
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