Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease
Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease
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DOI：
10.1007/s00330-003-2051-0
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发表时间：
2004-04-01
影响因子：
5.9
通讯作者：
Sturm, V
中科院分区：
文献类型：
--
作者：
Hesselmann, V;Sorger, B;Sturm, V
本文介绍了术中功能磁共振成像（fMRI）监测帕金森病患者脑深部电刺激（DBS）效果的技术方面。在运动激活下，丘脑底核的治疗性高频刺激伴随着对侧初级感觉运动皮层和同侧小脑的激活减少。此外，在对侧基底神经节和海马区的激活增加被检测到。这些研究结果表明，功能磁共振成像构成了一个有前途的临床应用调查脑活动的变化引起的DBS。
This article deals with technical aspects of intraoperative functional magnetic resonance imaging (fMRI) for monitoring the effect of deep brain stimulation (DBS) in a patient with Parkinson's disease. Under motor activation, therapeutic high-frequency stimulation of the subthalamic nucleus was accompanied by an activation decrease in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum. Furthermore, an activation increase in the contralateral basal ganglia and insula region were detected. These findings demonstrate that fMRI constitutes a promising clinical application for investigating brain activity changes induced by DBS.