Candida albicans Agglutinin-Like Sequence (Als) Family Vignettes: A Review of Als Protein Structure and Function.
Candida albicans Agglutinin-Like Sequence (Als) Family Vignettes: A Review of Als Protein Structure and Function.
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DOI：
10.3389/fmicb.2016.00280
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发表时间：
2016
影响因子：
5.2
通讯作者：
Cota E
中科院分区：
文献类型：
--
作者：
Hoyer LL;Cota E
自描述白色念珠菌ALS（凝集素样序列）家族中的第一个基因以来，已经过去了大约二十年。从那时起，人们对该家族的组成及其编码的细胞表面糖蛋白的功能有了很大的了解。解决方案的Als粘附结构域的结构提供了机会，以评估蛋白质功能的分子基础。这篇综述文章被格式化为一系列的基本问题，并探讨了Als蛋白的多样性，以及它们在配体结合，聚集效应和附着到非生物表面中的作用。Als蛋白彼此之间的相互作用，它们的功能等效性，以及蛋白质丰度对表型结论的影响也进行了研究。Als蛋白的结构特征，可能有助于侵入性功能被认为是。这些结论得到了文献的有力支持，同时强调了需要进一步研究的领域，以揭示Als蛋白的基本特征，它们之间的相关性以及它们在C.白色念珠菌生物学
Approximately two decades have passed since the description of the first gene in the Candida albicans ALS (agglutinin-like sequence) family. Since that time, much has been learned about the composition of the family and the function of its encoded cell-surface glycoproteins. Solution of the structure of the Als adhesive domain provides the opportunity to evaluate the molecular basis for protein function. This review article is formatted as a series of fundamental questions and explores the diversity of the Als proteins, as well as their role in ligand binding, aggregative effects, and attachment to abiotic surfaces. Interaction of Als proteins with each other, their functional equivalence, and the effects of protein abundance on phenotypic conclusions are also examined. Structural features of Als proteins that may facilitate invasive function are considered. Conclusions that are firmly supported by the literature are presented while highlighting areas that require additional investigation to reveal basic features of the Als proteins, their relatedness to each other, and their roles in C. albicans biology.