Gankyrin promotes the proliferation of human pancreatic cancer
Gankyrin promotes the proliferation of human pancreatic cancer
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Gankyrin 促进人类胰腺癌的增殖
DOI：
10.1016/j.canlet.2010.04.019
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发表时间：
2010-11-01
期刊：
影响因子：
9.7
通讯作者：
Fan, Daiming
中科院分区：
文献类型：
--
作者：
Meng, Yun;He, Lijie;Fan, Daiming
我们实验室以前的研究表明，gankyrin的表达与结直肠癌的恶性表型有关。在这里，我们研究了甘草蛋白在胰腺癌发生中的可能作用。Gankyrin在胰腺癌组织中的表达显著高于非癌组织。这种表达显著促进了癌细胞的体外和体内生长和增殖。抑制甘结蛋白下调细胞周期蛋白A、细胞周期蛋白D1、细胞周期蛋白E、CDK2、CDK4、增殖细胞核抗原和p-Rb的表达，上调p27、Rb和P53的表达。然而，Gankyrin的过度表达导致了相反的结果。因此，甘草蛋白可能通过促进细胞周期进程和P53的降解来促进胰腺癌细胞的增殖。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
Previous studies in our laboratory have suggested that gankyrin expression is correlated with a malignant phenotype in colorectal cancer. Here, we investigated the possible role of gankyrin in pancreatic carcinogenesis. Gankyrin expression was significantly increased in pancreatic cancer compared to non-cancerous tissues. This expression significantly enhanced cancer cell proliferation and growth in vitro and in vivo. Suppression of gankyrin downregulated cyclin A, cyclin D1, cyclin E, CDK2, CDK4, PCNA and p-Rb but upregulated p27, Rb and p53. However, gankyrin overexpression led to opposite results. Thus, gankyrin could enhance pancreatic cancer cell proliferation by promoting cell cycle progression and p53 degradation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.