Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes
Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes
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DOI：
10.1021/acs.orglett.9b00427
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发表时间：
2019-03-01
期刊：
影响因子：
5.2
通讯作者：
Cook, Silas P.
中科院分区：
文献类型：
--
作者：
Marcyk, Paul T.;Cook, Silas P.
经过100多年的探索，烯烃的氢化功能化提供了一种直接的、原子经济的方法来生产增值产品的可能性。虽然热力学上是有利的，但此类过程的动力学障碍需要使用催化剂来控制选择性和反应活性。现代的变体通常依赖于贵金属，每类氢功能化需要不同的配体，从而限制了通用性。这封信描述了一种普通的铁基体系，它催化简单的未活化烯烃的氢胺化和氢醚化。
The hydrofunctionalization of alkenes, explored for over 100 years, offers the potential for a direct, atom-economical approach to value-added products. While thermodynamically favored, the kinetic barrier to such processes necessitates the use of catalysts to control selectivity and reactivity. Modern variants typically rely on noble metals that require different ligands for each class of hydrofunctionalization, thereby limiting generality. This Letter describes a general iron-based system that catalyzes the hydroamination and hydroetherification of simple unactivated olefins.