Cytokine production after influenza vaccination in a healthy elderly population
Cytokine production after influenza vaccination in a healthy elderly population
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DOI：
10.1016/s0264-410x(98)00140-6
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发表时间：
1998-11-01
期刊：
影响因子：
5.5
通讯作者：
Murasko, DM
中科院分区：
文献类型：
--
作者：
Bernstein, ED;Gardner, EM;Murasko, DM
接种流感疫苗对老年人不如对年轻人有效。为了描述这种与年龄相关的流感疫苗免疫应答下降的特征，在免疫接种前和接种后4周，对居住在8个当地持续护理退休社区（CCRC）的270名健康老年人（平均年龄：80.2岁）和30名年轻人（平均年龄：27.8岁）的人群进行了流感疫苗抗体和细胞介导的应答评估。接种疫苗后，年轻人和老年人对所有三种流感病毒株产生的抗体滴度均显著增加（p
Influenza vaccination is less efficacious in the elder-ly than in the young. To characterize this age-related decrease in immune response to influenza vaccination, antibody and cell-mediated responses to influenza vaccine were assessed before immunization and 4 weeks after vaccination of a population of 270 healthy elderly individuals (mean age: 80.2 years) living in eight local continuing care retirement communities (CCRCs) and 30 young individuals (mean age: 27.8 years). The antibody titres produced against all three influenza strains increased significantly after vaccination in both the young and elderly (p