Functionally Brain Network Connected to the Retrosplenial Cortex of Rats Revealed by 7T fMRI.
Functionally Brain Network Connected to the Retrosplenial Cortex of Rats Revealed by 7T fMRI.
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7T fMRI 显示与大鼠脾后皮质相连的功能性大脑网络。
DOI：
10.1371/journal.pone.0146535
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Shan B
中科院分区：
文献类型：
--
作者：
Wang J;Nie B;Duan S;Zhu H;Liu H;Shan B
功能网络被认为是增加我们对健康和疾病状态下大脑功能的理解的重要机制，人们对将功能网络的研究扩展到动物模型越来越感兴趣，因为这些模型提供了对疾病进展、治疗和修复的功能理解。在啮齿类动物中，脾后皮质(RSC)是一个重要的皮质区域，因为它的体积很大，并在新皮质和大脑皮层之间呈现出过渡的层状图案。此外，一些侵入性研究强调了RSC在许多功能中的重要性。然而，基于啮齿动物RSC的网络仍不清楚。基于RSC的重要性，我们将双边RSC定义为两个感兴趣的区域，并基于RSC估计网络。结果表明，相关区域包括顶叶联合皮质、海马体、丘脑核、中脑结构和下丘脑乳头体。我们的发现指出了两个可能的主要网络：一个是感觉-认知网络，它在RSC中有一个中枢，处理感觉信息、空间学习和情景记忆；第二个网络涉及内脏功能和觉醒的调节。此外，还观察到双侧RSC之间的功能不对称。
Functional networks are regarded as important mechanisms for increasing our understanding of brain function in healthy and diseased states, and increased interest has been focused on extending the study of functional networks to animal models because such models provide a functional understanding of disease progression, therapy and repair. In rodents, the retrosplenial cortex (RSC) is an important cortical region because it has a large size and presents transitional patterns of lamination between the neocortex and archicortex. In addition, a number of invasive studies have highlighted the importance of the RSC for many functions. However, the network based on the RSC in rodents remains unclear. Based on the critical importance of the RSC, we defined the bilateral RSCs as two regions of interest and estimated the network based on the RSC. The results showed that the related regions include the parietal association cortex, hippocampus, thalamus nucleus, midbrain structures, and hypothalamic mammillary bodies. Our findings indicate two possible major networks: a sensory-cognitive network that has a hub in the RSCs and processes sensory information, spatial learning, and episodic memory; and a second network that is involved in the regulation of visceral functions and arousal. In addition, functional asymmetry between the bilateral RSCs was observed.