Identification of a particular HIV-specific CD8+ T-cell subset with a CD27+ CD45RO-/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection
Identification of a particular HIV-specific CD8+ T-cell subset with a CD27+ CD45RO-/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection
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DOI：
10.1182/blood-2008-07-167601
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发表时间：
2009-04-02
期刊：
影响因子：
20.3
通讯作者：
Venet, Alain
中科院分区：
文献类型：
--
作者：
Lecuroux, Camille;Girault, Isabelle;Venet, Alain
CD8(+) T细胞在控制病毒感染中发挥着重要作用。 HIV 感染期间 CD8(+) T 细胞反应缺陷可能导致病毒持续存在。在急性原发性 HIV 感染期间及早开始高效抗逆转录病毒治疗有助于保持 HIV 特异性免疫反应。在这里，我们描述了在原发感染早期接受治疗的参与者中特定的 CD27(+) CD45RO(-)/RA(+) HIV 特异性 CD8(+) T 细胞。这些细胞在原发性艾滋病毒感染期间以非常低的频率存在，但在早期治疗后显着增加，而在未经治疗的参与者和后来接受治疗的参与者中，它们的频率保持不变。这些非幼稚抗原经历过的细胞处于静息状态，并具有长寿命记忆细胞的特征。它们还具有直接效应能力，例如细胞因子产生，并且能够增殖并在重新激活时获得细胞毒功能。我们的结果表明，当早期病毒复制受到抑制时，观察到这些HIV特异性CD27(+) CD45RO(-)/RA(+) CD8(+) T细胞形成具有记忆特征的静息细胞池。 （血。2009；113：3209-3217）
CD8(+) T cells play an important role in controlling viral infections. Defective CD8(+) T-cell responses during HIV infection could contribute to viral persistence. Early initiation of highly active antiretroviral therapy during acute primary HIV infection helps to preserve HIV-specific immune responses. Here, we describe a particular CD27(+) CD45RO(-)/RA(+) HIV-specific CD8(+) T cell in participants treated early during the primary infection. These cells, which were present at a very low frequency during primary HIV infection, increased markedly after early treatment, whereas their frequency remained unchanged in untreated participants and in participants treated later. These nonnaive antigen-experienced cells are in a resting state and have characteristics of long-lived memory cells. They also possess direct effector capabilities, such as cytokine production, and are able to proliferate and to acquire cytotoxic functions on reactivation. Our results suggest that these HIV-specific CD27(+) CD45RO(-)/RA(+) CD8(+) T cells, observed when early viral replication is inhibited, form a pool of resting cells with memory characteristics. (Blood. 2009; 113:3209-3217)