Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages
Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages
复制标题
DOI：
10.1093/infdis/jix509
复制
发表时间：
2018-02-15
影响因子：
6.4
通讯作者：
Barr, Ian G.
中科院分区：
文献类型：
--
作者：
Laurie, Karen L.;Horman, William;Barr, Ian G.
背景两种B型流感病毒谱系，B/维多利亚和B/Yamagata，在人群中共同传播。虽然谱系是血清学上不同的，交叉反应的反应，这两个谱系已被检测到。病毒干扰描述了一种病毒感染限制第二种病毒感染和复制的情况。我们研究了流感B病毒株之间病毒干扰的可能性。感染雪貂，然后在3、10或28天后用流感B/维多利亚和B/Yamagata病毒对进行攻击。病毒干扰发生在攻毒间隔3和10天，偶尔在28天。在较长的时间间隔内，攻击病毒的脱落减少，这与交叉反应性干扰素相关。病毒感染动物的淋巴结反应。来自两个谱系的病毒可以预防或显著限制来自另一谱系的病毒的后续感染。合并感染是罕见的，表明谱系之间的重配的可能性是有限的。这些数据表明，先天性和交叉反应性免疫介导病毒干扰，这可能有助于在任何给定的流感季节中特定的流感B病毒谱系的优势。此外，感染一种B型流感病毒谱系可有益于防止随后感染任一种B型流感病毒谱系。
Background. Two influenza B virus lineages, B/Victoria and B/Yamagata, cocirculate in the human population. While the lineages are serologically distinct, cross-reactive responses to both lineages have been detected. Viral interference describes the situation whereby infection with one virus limits infection and replication of a second virus. We investigated the potential for viral interference between the influenza B virus lineages.Methods. Ferrets were infected and then challenged 3, 10, or 28 days later with pairs of influenza B/Victoria and B/Yamagata viruses.Results. Viral interference occurred at challenge intervals of 3 and 10 days and occasionally at 28 days. At the longer interval, shedding of challenge virus was reduced, and this correlated with cross-reactive interferon. responses from lymph nodes from virus-infected animals. Viruses from both lineages could prevent or significantly limit subsequent infection with a virus from the other lineage. Coinfections were rare, indicating the potential for reassortment between lineages is limited.Conclusions. These data suggest that innate and cross-reactive immunity mediate viral interference and that this may contribute to the dominance of a specific influenza B virus lineage in any given influenza season. Furthermore, infection with one influenza B virus lineage may be beneficial in protecting against subsequent infection with either influenza B virus lineage.