GENOMIC REORGANIZATION AND DISRUPTED CHROMOSOMAL SYNTENY IN THE SIAMANG (HYLOBATES SYNDACTYLUS) REVEALED BY FLUORESCENCE IN-SITU HYBRIDIZATION
GENOMIC REORGANIZATION AND DISRUPTED CHROMOSOMAL SYNTENY IN THE SIAMANG (HYLOBATES SYNDACTYLUS) REVEALED BY FLUORESCENCE IN-SITU HYBRIDIZATION
复制标题
DOI：
10.1002/ajpa.1330970104
复制
发表时间：
1995-05-01
影响因子：
2.8
通讯作者：
STANYON, R
中科院分区：
文献类型：
--
作者：
KOEHLER, U;ARNOLD, N;STANYON, R
我们利用人类所有染色体的染色体特异DNA文库的原位杂交(染色体涂色)来建立人类和暹罗的核型之间的同源性(Hylobates syndactylus，2n=50)。许多染色体内和染色体间的重排导致了siamang核型的大规模重组。至少有33例易位。这24个暹曼常染色体由60个可识别的片段组成，这些片段显示了与22个人类常染色体区域的DNA同源性。只有两个常染色体没有参与易位。在一种与人类关系密切的灵长类动物中，暹猴的染色体形态和同步性受到高度干扰，其方式类似于啮齿类动物。(C)1995年Wiley-Liss公司
We employed in situ hybridization (''chromosome painting'') of chromosome-specific DNA libraries of all human chromosomes to establish homologies between the human and siamang karyotypes (Hylobates syndactylus, 2n = 50). Numerous intra- and interchromosomal rearrangements have led to a massive reorganization of the siamang karyotype. There have been a minimum of 33 translocations. The 24 siamang autosomes are composed of 60 recognizable segments that show DNA homology to regions of the 22 human autosomes. Only two autosomes have not been involved in translocations. The siamang presents a case, in a primate closely related to humans, in which chromosome morphology and synteny are highly disturbed in a manner similar to that encountered among rodents. (C) 1995 Wiley-Liss, Inc.