Localizing the corticospinal neurons in neonatal, developing and mature albino rat
Localizing the corticospinal neurons in neonatal, developing and mature albino rat
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定位新生、发育和成熟白化大鼠的皮质脊髓神经元
DOI：
10.1016/0006-8993(83)91327-6
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发表时间：
1983
期刊：
影响因子：
2.9
通讯作者：
S. Leong
中科院分区：
文献类型：
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作者：
S. Leong
在新生（1-10天）、发育（15-20天）和成熟（2-4个月）白化病大鼠颈髓中段或下段注射辣根过氧化物酶（HRP）后，在大脑皮质V层发现标记的锥体神经元。它们在新生动物的额叶和顶叶同皮层形成一个连续的标记神经元带。这条带开始于额极附近，向远端延伸约3600 μm。内侧，束带的外侧界限位于鼻沟的背唇处。沿着大脑半球内侧表面的“肩”区的神经元也被标记。随着动物年龄的增长，标记顶叶带中的锥体神经元变得越来越困难。15日龄大鼠顶骨区的条带出现断裂和不连续。在20日龄和成熟大鼠的标记神经元出现在两个带，背外侧和顶叶之一，这两个被分开的变量间隙的皮质几乎没有或很少的神经元标记。标记的神经元在“肩膀”区域明显地看到，只有在吻侧区的额叶皮质在老年动物。在腰骶部脊髓节段注射HRP后，2日龄大鼠未见标记的V层锥体神经元，而5日龄及以上大鼠的大脑皮质背外侧部可见标记的V层锥体神经元形成一条连续的带状。它们出现在一个caudo-rostral序列，与神经元在大脑皮质的尾部部分的神经元投射到更多的尾侧脊髓段和那些在额叶部分的更多的吻侧脊髓段。中间外侧带宽约2 mm。在新生儿和发育中的动物中，“肩”区的神经元很少见到。
Following the administration of horseradish peroxidase (HRP) in the middle or lower cervical cord segments of neonatal (1–10 days), developing (15–20 days) and mature (2–4 months) albino rats, labeled pyramidal neurons were found in layer V of the cerebral cortex. They formed one continuous band of labeled neurons in the frontal and parietal isocortex in neonatal animals. The band began close to the frontal pole and extended distally for about 3600 μm. Mediolaterally the lateral limit of the band was at the dorsal lip of the rhinal sulcus. Neurons in the ‘shoulder’ region along the medial surface of the cerebral hemisphere were also labeled. As the animals increased in age it became increasingly more difficult to label the pyramidal neurons in the parietal band. The band appeared broken and discontinuous in the parietal region in the 15-day-old rats. In the 20-day-old and mature rats the labeled neurons appeared in two bands, a dorsolateral one and a parietal one, the two being separated by a variable gap of cortex where practically no or very few neurons were labeled. Labeled neurons in the ‘shoulder’ region were distinctly seen only in the rostral region of the frontal isocortex in older animals. Following the administration of HRP in lumbosacral cord segments, no labeled layer V pyramidal neurons were seen in the 2-day-old rats, but they were seen to form one continuous band in the dorsolateral part of the cerebral cortex in rats aged 5 days postnatally and older. They appeared in a caudo-rostral sequence, with neurons in the caudal part of the cerebral cortex projecting to the more caudal cord segments and those in the frontal part to the more rostral cord segments. Mediolaterally the band was about 2 mm wide. Neurons in the ‘shoulder’ region were infrequently seen in neonatal and developing animals.