Corneal refractive surgery with femtosecond lasers
Corneal refractive surgery with femtosecond lasers
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DOI：
10.1109/2944.796309
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发表时间：
1999-07-01
影响因子：
4.9
通讯作者：
Mourou, G
中科院分区：
文献类型：
--
作者：
Juhasz, T;Frieder, H;Mourou, G
我们研究了超短脉冲（飞秒）激光技术在角膜屈光手术中的应用。与脉宽较长的纳秒或皮秒激光脉冲相比，飞秒激光-组织相互作用的特征在于显著更小且更确定的光致破裂能量阈值，以及减少的冲击波和更小的空化气泡。我们在所有研究中使用了高度可靠的全固态飞秒激光系统，以证明在真实操作条件下的实用性。角膜接触组织的影响，通过扫描一个5 μ m的聚焦激光点下的角膜表面的脉冲能量约2-4 μ J。各种扫描模式被用来执行三个原型程序在动物的眼睛，角膜瓣切割，角膜磨镶术，和基质内视力矫正。对于板层手术（角膜瓣切割和角膜磨镶术），获得了上级解剖和表面质量结果。基质内视力矫正的初步体内研究表明，该方法也可以实现一致的屈光变化。我们的结论是，飞秒激光技术可能能够执行各种高精度的角膜屈光手术，提供优于目前的机械和激光设备和技术。
We investigated the use of ultrashort pulsed (femtosecond) laser technology in corneal refractive surgery, When compared to longer pulsewidth nanosecond or picosecond laser pulses, femtosecond laser-tissue interactions are characterized by significantly smaller and more deterministic photodisruptive energy thresholds, as well as reduced shock waves and smaller cavitation bubbles. We utilized a highly reliable all solid state femtosecond laser system for all studies to demonstrate practicality in real-world operating conditions. Contiguous tissue effects were achieved by scanning a 5-mu m focused laser spot below the corneal surface at pulse energies of approximately 2-4 mu J. A variety of scanning patterns was used to perform three prototype procedures in animal eyes; corneal flap cutting, keratomileusis, and intrastromal vision correction. Superior dissection and surface quality results were obtained for lamellar procedures (corneal flap cutting and keratomileusis), Preliminary in vivo studies of intrastromal vision correction suggest that consistent refractive changes can also be achieved with this method. We conclude that femtosecond laser technology may be able to perform a variety of corneal refractive procedures with high precision, offering advantages over current mechanical and laser devices and techniques.