Tissue response to titanium implantation in the rat maxilla, with special reference to the effects of surface conditions on bone formation
Tissue response to titanium implantation in the rat maxilla, with special reference to the effects of surface conditions on bone formation
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DOI：
10.1046/j.0905-7161.2003.00960.x
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发表时间：
2003-12-01
影响因子：
4.3
通讯作者：
Maeda, T
中科院分区：
文献类型：
--
作者：
Shirakura, M;Fujii, N;Maeda, T
在我们建立的大鼠上颌骨种植模型中，通过光镜和透射电镜以及抗酒石酸酸性磷酸酶（TRANS 3）活性的组织化学研究了两种不同表面条件的钛植入的组织反应。在这里，我们使用了两种类型的种植体具有不同的表面质量：钛种植体喷砂氧化铝（SA组）和种植体涂层羟基磷灰石（HA组）。在两组中，当准备好的骨腔中的炎症反应几乎消失时，在植入后5天开始骨形成。然而，在SA组中，骨腔中的骨形成过程与我们之前使用光滑表面种植体的报告（Futami等，2000）中所示的几乎相同：从预先存在的骨向种植体发生的新骨形成之前，在具有窄间隙的外侧区域发生主动骨吸收，但在具有宽间隙的基底区域则不然。在HA组中，在外侧和基底区域均可识别出从植入物朝向预先存在的骨的直接骨形成。在植入物表面附近发现许多TRAPase-reactive细胞。在原有骨上，新骨形成伴随典型破骨细胞的骨吸收。SA组和HA组在术后第28天实现了种植体周围的骨整合，但外侧区域除外，在外侧区域，种植体安装在靠近腔缘的位置。这些发现表明钛植入物周围的骨化以不同的模式进行，可能取决于表面性质和质量。
Tissue responses to titanium implantation with two different surface conditions in our established implantation model in rat maxillae were investigated by light and transmission electron microscopy and by histochemistry for tartrate-resistant acid phosphatase (TRAPase) activity. Here we used two types of implants with different surface qualities: titanium implants sandblasted with Al2O3 (SA-group) and implants coated with hydroxyapatite (HA-group). In both groups, bone formation had begun by 5 days postimplantation when the inflammatory reaction had almost disappeared in the prepared bone cavity. In the SA-group, however, the bone formation process in the bone cavity was almost identical to that shown in our previous report using smooth surfaced implants (Futami et al. 2000): new bone formation, which occurred from the pre-existing bone toward the implant, was preceded by active bone resorption in the lateral area with a narrow gap, but not so in the base area with a wide gap. In the HA-group, direct bone formation from the implant toward the pre-existing bone was recognizable in both lateral and base areas. Many TRAPase-reactive cells were found near the implant surface. On the pre-existing bone, new bone formation occurred with bone resorption by typical osteoclasts. Osseointegration around the implants was achieved by postoperative day 28 in both SA- and HA-groups except for the lateral area, where the implant had been installed close to the cavity margin. These findings indicate that ossification around the titanium implants progresses in different patterns, probably dependent on surface properties and quality.