Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma
Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma
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DOI：
10.1055/s-0031-1276589
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发表时间：
2011-06-01
影响因子：
5.7
通讯作者：
Ranson, Marie
中科院分区：
文献类型：
--
作者：
Lee, Jodi A.;Cochran, Blake J.;Ranson, Marie
纤溶酶原激活物抑制剂（派）-2表达在妊娠、炎症、感染和其他病理生理条件下急剧上调。阻止派-2上调的情况与慢性病理学相关。总之，这强烈表明派-2是在损伤或应激期间维持体内平衡的许多蛋白质之一。然而，从经典的丝氨酸蛋白酶抑制剂到各种细胞内作用的几种功能已被归因于派-2，并且因为这些功能中没有一个在体内被明确证实，所以直到今天，其确切的作用仍然是一个谜。本文综述了派-2在细胞外环境中纤维蛋白溶解和蛋白溶解中的作用，并回顾了派-2的许多潜在的细胞内功能。
Plasminogen activator inhibitor (PAI)-2 expression is acutely upregulated in pregnancy, inflammation, infection, and other pathophysiological conditions. Circumstances that prevent PAI-2 upregulation are associated with chronic pathology. Altogether this strongly suggests that PAI-2 is one of the many proteins that maintain homeostasis during damage or stress. However, several functions ranging from a classical serpin to various intracellular roles have been ascribed to PAI-2 and, because none of these have been definitively proven in vivo, to this day its precise role or roles remains an enigma. This review readdresses the evidence supporting a role for PAI-2 in fibrinolysis and proteolysis within extracellular environments and includes a review of the many potential intracellular functions attributed to PAI-2.