Magnetic field enhancement of antibiotic activity in biofilm forming Pseudomonas aeruginosa.
Magnetic field enhancement of antibiotic activity in biofilm forming Pseudomonas aeruginosa.
复制标题
磁场增强铜绿假单胞菌生物膜形成中的抗生素活性。
DOI：
10.1097/00002480-199407000-00025
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Mohammad,SF
中科院分区：
文献类型：
--
作者：
Benson,DE;Grissom,CB;Burns,GL;Mohammad,SF
由生物膜细菌引发的设备相关感染通常很难通过抗菌治疗来解决。研究结果表明，施加静磁场可以增强庆大霉素对抗粘附在聚合物基质上形成生物膜的铜绿假单胞菌的活性。结果表明，与暴露于 5 高斯 (G) 磁场和庆大霉素的样品的对照相比，粘附活细菌的数量最大减少了 86.5±7.2%(n= 6)。该效应似乎仅限于 5 至 20 G 之间的磁场。使用玻璃、Chronoflex（Polymedica，Golden，CO）、Biomer（Ethicon，萨默维尔，新泽西州）和聚苯乙烯基材进行的实验表明，该效应与基材表面无关。 In 111 吸收实验的放射自显影图表明，在经过磁场和庆大霉素的样品中，定植于基质表面的细菌显着减少。
Device related infection initiated by biofilm bacteria are often difficult to resolve with antimicrobial therapy. Study results indicate that application of static magnetic fields may enhance the activity of gentamicin against biofilm forming Pseudomonas aeruginosa adherent to a polymer substrate. Results indicate a maximal reduction of 86.5±7.2%(n= 6) in the number of adherent viable bacteria compared with a control for samples exposed to a 5 gauss (G) magnetic field and gentamicin. The effect appears to be limited to magnetic fields between 5 and 20 G. Experiments using glass, Chronoflex (Polymedica, Golden, CO), Biomer (Ethicon, Somerville, NJ), and polystyrene substrate showed that the effect was independent of substrate surface. Autoradiograms from In 111 uptake experiments showed that bacteria colonizing the substrate surface were significantly reduced in samples subjected to a magnetic field and gentamicin.