The acetaldehyde content in rat brain during ethanol metabolism
The acetaldehyde content in rat brain during ethanol metabolism
复制标题
乙醇代谢过程中大鼠脑内乙醛含量
DOI：
10.1111/j.1471-4159.1974.tb04380.x
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发表时间：
1974
影响因子：
4.7
通讯作者：
H. Sippel
中科院分区：
文献类型：
--
作者：
H. Sippel
乙醛是在乙醇的肝脏氧化过程中形成的，被认为会产生许多在饮酒后观察到的影响（WALSH, 1971）。其中之一是乙醇与脑内生物胺代谢之间的相互作用（TRUITT & WALSH, 1971）。乙醛对醛脱氢酶的竞争性抑制可能会抑制来自不同生物胺的醛的氧化（LAHTI & MAJCHROWICZ, 1969； DAVIS, 1971），并导致具有药理活性的醛的积累（TABAKOFF等人，1972）。乙醛和生物胺之间的直接反应形成具有药理活性的缩合产物也有报道（COHEN, 1971）。此外，乙醛本身具有良好的间接拟交感神经效应（WALSH, 1971）。尽管乙醛对乙醇的影响很重要，但只有少数关于乙醇处理后大脑中乙醛水平的报道（KIESSLING, 1962； RIDGE, 1963; DURITZ & TRUITT, 1966）。检测到的乙醛含量等于或高于相应的血液浓度。本研究研究了单剂量乙醇对大鼠脑内乙醛含量的影响。
ACETALDEHYDE, formed in the hepatic oxidation of ethanol, has been postulated to produce many of the effects observed after alcohol consumption (WALSH, 1971). One of these is the interaction between ethanol and the metabolism of biogenic amines in brain (TRUITT & WALSH, 1971). The competitive inhibition of aldehyde dehydrogenase by acetaldehyde may inhibit the oxidation of the aldehydes derived from different biogenic amines (LAHTI & MAJCHROWICZ, 1969; DAVIS, 1971) and cause an accumulation of pharmacologically active aldehydes (TABAKOFF et al., 1972). Condensation products with pharmacological activity formed by a direct reaction between acetaldehyde and biogenic amines have also been reported (COHEN, 1971). Moreover, acetaldehyde itself has a well documented indirect sympathomimetic effect (WALSH, 1971). Despite the importance of acetaldehyde in contributing to the effects of ethanol, there are only a few reports about acetaldehyde levels in the brain following ethanol administration (KIESSLING, 1962; RIDGE, 1963; DURITZ & TRUITT, 1966). The acetaldehyde levels found have been equal to or higher than the corresponding blood concentrations. This study investigates the acetaldehyde content in rat brain after the administration of a single dose of ethanol.