Factors influencing the decline in lung density in a Danish lung cancer screening cohort
Factors influencing the decline in lung density in a Danish lung cancer screening cohort
复制标题
影响丹麦肺癌筛查队列中肺密度下降的因素
DOI：
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发表时间：
2012
影响因子：
24.3
通讯作者：
J. Pedersen
中科院分区：
文献类型：
--
作者：
S. Shaker;A. Dirksen;P. Lo;L. Skovgaard;Marleen de Bruijne;J. Pedersen
肺癌筛查试验提供了利用CT肺密度作为替代参数研究肺气肿自然病史的机会。在丹麦肺癌筛查试验中，有2052名参与者。在筛查过程中，记录吸烟习惯并进行肺活量测定。CT肺密度测量为体积调整的第15百分位密度(PD15)。一种混合效应模型被用来作为参照组，研究对象为有30年烟龄且入院时无气流障碍(AFO)的男性吸烟者。在研究开始时，893名(44%)参与者有AFO。对照组的PD15值为72.6g·L−1，年降幅为-0.33g·L−1。女性和既往吸烟者的PD15值在基线水平分别为17.3g·L−1(p<；0.001)和10g·L−1(p<；0.001)，且均增加了PD15年降幅(女性：-0.3g·L−1；现吸烟组：-0.4g·L−1)。AFO的存在和严重程度是基线水平低PD15值(全球慢性阻塞性肺疾病倡议(GOLD)I：-1.4g·L−1；GOLD II：-6.3g·L−1；GOLD III：-17g·L−1)和PD15年下降加剧的有力预测因素(GOLD I：-0.2g·L−1；GOLD II：-0.5g·L−1；GOLD III：-0.5g·L−1)。女性、主动吸烟和AFO的存在与肺密度加速下降有关。
Lung cancer screening trials provide an opportunity to study the natural history of emphysema by using computed tomography (CT) lung density as a surrogate parameter. In the Danish Lung Cancer Screening Trial, 2,052 participants were included. At screening rounds, smoking habits were recorded and spirometry was performed. CT lung density was measured as the volume-adjusted 15th percentile density (PD15). A mixed effects model was used with former smoking males with <30 pack-yrs and without airflow obstruction (AFO) at entry as a reference group. At study entry, 893 (44%) participants had AFO. For the reference group, PD15 was 72.6 g·L−1 with an annual decline of -0.33 g·L−1. Female sex and current smoking increased PD15 at baseline, 17.3 g·L−1 (p<0.001) and 10 g·L−1 (p<0.001), respectively; and both increased the annual decline in PD15 (female: -0.3 g·L−1; current smoking: -0.4 g·L−1). The presence and severity of AFO was a strong predictor of low PD15 at baseline (Global Initiative for Chronic Obstructive Lung Disease (GOLD) I: -1.4 g·L−1; GOLD II: -6.3 g·L−1; GOLD III: -17 g·L−1) and of increased annual decline in PD15 (GOLD I: -0.2 g·L−1; GOLD II: -0.5 g·L−1; GOLD III: -0.5 g·L−1). Female sex, active smoking and the presence of AFO are associated with accelerated decline in lung density.
DOI：
10.1164/rccm.200812-1966oc
发表时间：
2009-09-01
影响因子：
24.7
作者：
Lederer, David J.;Enright, Paul L.;Barr, R. Graham
通讯作者：
Barr, R. Graham