The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases.
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases.
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DOI：
10.1016/j.bbamcr.2009.01.016
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Tanaka K
中科院分区：
文献类型：
--
作者：
Yue Z;Friedman L;Komatsu M;Tanaka K
自噬是一种严格调控的细胞自噬过程。它已被证明与各种神经病理学状况有关，因此传统上被称为压力诱发过程。然而，最近的研究表明，自噬在健康神经元中持续活跃。神经元是高度特化的有丝分裂后细胞，通常由胞体（细胞体）、树突树和轴突组成。尽管我们目前对自噬的了解有了很大的增长，但这种高度分化的细胞类型的详细过程仍然难以捉摸。目前的证据强烈表明，自噬在神经元中受到独特的调节，并且也高度适应轴突的局部生理机能。此外，神经元基础自噬的分子机制可能与“经典”诱导的自噬显着不同。大量研究越来越多地表明自噬在神经退行性疾病中的重要作用，并探索自噬作为潜在的药物靶点。因此，了解神经元自噬过程最终将有助于药物靶点识别和合理设计药物筛选以对抗神经退行性疾病。
Autophagy is a tightly regulated cell self-eating process. It has been shown to be associated with various neuropathological conditions and therefore, traditionally known as a stress-induced process. Recent studies, however, reveal that autophagy is constitutively active in healthy neurons. Neurons are highly specialized, post-mitotic cells that are typically composed of a soma (cell body), a dendritic tree, and an axon. Despite the vast growth of our current knowledge of autophagy, the detailed process in such a highly differentiated cell type remains elusive. Current evidence strongly suggests that autophagy is uniquely regulated in neurons and is also highly adapted to local physiology in the axons. In addition, the molecular mechanism for basal autophagy in neurons may be significantly divergent from “classical” induced autophagy. A considerable number of studies has increasingly shown an important role for autophagy in neurodegenerative diseases and has explored autophagy as a potential drug target. Thus, understanding the neuronal autophagy process will ultimately aid in drug target identification and rational design of drug screening to combat neurodegenerative diseases.
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影响因子：
5.3
作者：
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影响因子：
4.7
作者：
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影响因子：
5.3
作者：
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通讯作者：
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