MicroRNAs in skeletal muscle biology and exercise adaptation.
MicroRNAs in skeletal muscle biology and exercise adaptation.
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DOI：
10.1016/j.freeradbiomed.2013.07.004
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发表时间：
2013-09
影响因子：
7.4
通讯作者：
McCarthy JJ
中科院分区：
文献类型：
--
作者：
Kirby TJ;McCarthy JJ
MicroRNAs （miRNAs）已经成为基因表达调控的重要参与者，参与了迄今为止研究的大多数生物过程。mirna主要参与细胞应激反应的建议使得mirna非常适合介导骨骼肌对收缩活动变化的反应。尽管该领域仍处于起步阶段，但本综述中提出的研究强调了mirna在调节骨骼肌对各种运动模式的反应和适应方面的重要作用。mirna在卫星细胞生物学、肌肉再生和各种肌病中的作用也进行了讨论。
MicroRNAs (miRNAs) have emerged as important players in the regulation of gene expression, being involved in most biological processes examined to date. The proposal that miRNAs are primarily involved in the stress response of the cell makes miRNAs ideally suited to mediate the response of skeletal muscle to changes in contractile activity. Although the field is still in its infancy, the studies presented in this review highlight the promise that miRNAs will have an important role in mediating the response and adaptation of skeletal muscle to various modes of exercise. The roles of miRNAs in satellite cell biology, muscle regeneration, and various myopathies are also discussed.