Measurement of biological washout rates depending on tumor vascular status in 15O in-beam rat-PET
Measurement of biological washout rates depending on tumor vascular status in 15O in-beam rat-PET
复制标题
15O 束内大鼠 PET 中生物洗脱率的测量取决于肿瘤血管状态
DOI：
10.1088/1361-6560/ac72f3
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yamaya Taiga
中科院分区：
文献类型：
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作者：
Toramatsu Chie;Mohammadi Akram;Wakizaka Hidekatsu;Sudo Hitomi;Nitta Nobuhiro;Seki Chie;Kanno Iwao;Takahashi Miwako;Karasawa Kumiko;Hirano Yoshiyuki;Yamaya Taiga
为了实现基于正电子发射断层扫描（PET）的带电粒子治疗剂量范围的定量验证，需要对正电子发射体的生物洗脱进行建模和校正。这种生物洗脱效果的影响，如血液灌注和代谢的生理环境条件，但相关的肿瘤病理学尚未studied you.ApproachThe本研究的目的是探讨依赖的生物洗脱率对肿瘤血管状态在大鼠照射。两种类型的肿瘤血管条件，灌注和缺氧，与裸大鼠建模。用放射性15O离子束照射大鼠，用动态在束PET测量获得时间活动曲线。取肿瘤组织切片观察组织学变化。结果肿瘤血管灌注组织的k2m值均高于正常组织，肿瘤血管灌注组织的k2m值与正常组织的k2s值相比有显著性差异（P <0.05）。所有k2m值在缺氧肿瘤组织中的值远低于血管灌注肿瘤组织的值，并略低于正常组织的值。
ObjectiveThe biological washout of positron emitters should be modeled and corrected in order to achieve quantitative dose range verification in charged particle therapy based on positron emission tomography (PET). This biological washout effect is affected by physiological environmental conditions such as blood perfusion and metabolism, but the correlation to tumour pathology has not been studied yet.ApproachThe aim of this study was to investigate the dependence of the biological washout rate on tumour vascular status in rat irradiation. Two types of tumour vascularity conditions, perfused and hypoxic, were modelled with nude rats. The rats were irradiated by a radioactive 15 O ion beam and time activity curves were acquired by dynamic in-beam PET measurement. Tumour tissue sections were obtained to observe the histology as well. The biological washout rate was derived using a single-compartment model with two decay components (medium decay, k 2m and slow decay, k 2s).Main resultsAll k 2m values in the vascular perfused tumour tissue were higher than the values of the normal tissue. All k 2m values in the hypoxic tumour tissue were much lower than the values of the vascular perfused tumour tissue and slightly lower than the values of the normal tissue.SignificanceThe dependency of the biological washout on the tumour vasculature conditions was experimentally shown.