APOE ε4 and Cognitive Function in Early Life: A Meta-Analysis
APOE ε4 and Cognitive Function in Early Life: A Meta-Analysis
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DOI：
10.1037/a0026769
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发表时间：
2012-05-01
期刊：
影响因子：
2.4
通讯作者：
Kliegel, Matthias
中科院分区：
文献类型：
--
作者：
Ihle, Andreas;Bunce, David;Kliegel, Matthias
前言：ILS已证实载脂蛋白E(ApoE)epsilon 4等位基因与老年认知障碍和阿尔茨海默病有关。相比之下，几项研究表明，年轻的epsilon 4携带者对认知有好处。因此，epsilon 4等位基因可能在整个一生中与认知呈多效性关联，而青年时期epsilon 4相关的益处反过来成为晚年认知障碍和痴呆症的风险因素。然而，到目前为止，还没有对评估儿童、青少年和年轻人APOE认知关联的工作进行广泛的量化审查。方法：在20项研究的基础上，对携带epsilon 4的青少年及其非epsilon 4携带者的认知成绩进行元分析，考察apoE epsilon 4相关的认知成绩差异。此外，我们评估了执行需求的水平是否影响了epsilon 4等位基因与认知测量之间的关联强度。结果：在所有分析中，估计的与apoE epsilon 4相关的群体效应大小并不可靠地不同于零。此外，任务的执行要求水平并不影响这一结果。结论：我们在年轻人、青少年和儿童中没有发现与APOE epsilon 4相关的认知益处，而且研究结果不受认知任务中执行需求水平的影响。因此，鉴于目前的经验证据，APOE epsilon 4与整个生命周期中的认知表现出多效性关联的说法应该谨慎对待。
Introduction: Ills well established that the Apolipoprotein E (APOE) epsilon 4 allele is associated with cognitive impairment and Alzheimer's disease in old age. By contrast, several studies have demonstrated cognitive benefits in young epsilon 4 carriers. It is therefore possible that the epsilon 4 allele exhibits a pleiotropic association with cognition across the life span where epsilon 4-related benefits in youth reverse to become risk factors for cognitive impairment and dementia in later life. To date, though, there has been no broad quantitative review of work assessing APOE-cognition associations in children, adolescents and young adults. Method: Based on 20 studies investigating cognitive performance in epsilon 4-carrying young persons and their non-epsilon 4 counterparts, a meta-analytic study was conducted to examine APOE epsilon 4-related differences in cognitive performance. Additionally, we assessed whether the level of executive demands affected the strength of associations between the epsilon 4 allele and cognitive measures. Results: In all analyses, estimated APOE epsilon 4-related population effect sizes did not reliably differ from zero. Furthermore, the level of executive demands of the task did not affect this finding. Conclusion: We found no APOE epsilon 4-related cognitive benefits in young adults, adolescents and children, and findings were not moderated by the level of executive demands in a cognitive task. Given the current empirical evidence therefore, suggestions that APOE epsilon 4 exhibits a pleiotropic association with cognition across the life span should be treated with caution.