Animal Models
Animal Models
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DOI：
10.1111/j.1399-0004.2009.01224.x
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发表时间：
2009-09
影响因子：
3.5
通讯作者：
Jacqueline N. Crawley;Jennifer Brielmaier
中科院分区：
文献类型：
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作者：
Jacqueline N. Crawley;Jennifer Brielmaier
国际，多学科临床和基础科学研究人员聚集在一起，讨论和确定增加各种模型对人类药物疗效和毒性的预测能力所需的变化，以及在代谢和心血管疾病，炎症，疼痛等领域的生物医学研究中进一步完善，减少和取代动物模型的方法。讨论的其他主题包括生物成像、生物模拟、生物信息学、转基因动物的产生、表型筛选、啮齿动物模型的替代品、胚胎干细胞的使用、患者特异性诱导多能干细胞和人源化动物模型等方面的新技术。本卷介绍了在这个重要的会议上讨论的一些主题的短篇论文集。
International, multi-disciplinary clinical and basic science investigators convened to discuss and identify changes needed to increase the predictive power of various models for drug efficacy and toxicity in humans, and ways in which to further refine, reduce, and replace animal models in biomedical research in areas such as metabolic and cardiovascular disease, inflammation, pain. Other topics discussed included new technologies in bioimaging, biosimulation, bioinformatics, the generation of genetically modified animals, phenotype screening, alternatives to rodent models, the use of embryonic stem cells, patient-specific induced pluripotent stem cells, and humanized animal models. This volume presents a collection of short papers on some of the topics discussed at this important conference.