Palliative Radiotherapy for Non-melanoma Skin Cancer
Palliative Radiotherapy for Non-melanoma Skin Cancer
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DOI：
10.1016/j.clon.2010.07.014
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发表时间：
2010-12-01
影响因子：
3.4
通讯作者：
Balogh, J.
中科院分区：
文献类型：
--
作者：
Barnes, E. A.;Breen, D.;Balogh, J.
本研究的主要目的是评估本中心使用的姑息性放疗方案对非黑素瘤皮肤癌的肿瘤反应率（8 Gy/分数，第0 ~ 21天），次要目的是评估症状缓解。材料和方法回顾性回顾了2003年8月至2008年12月接受姑息性放疗方案治疗的患者，患者年龄、性别、肿瘤组织学、位置、大小、症状和放疗在基线时记录治疗因素，在每个部分和随访时记录肿瘤大小和肿瘤相关症状，并对结果进行分析，目的是治疗基础。结果28例患者接受了31个疗程的姑息性放疗，治疗皮肤基底细胞癌（5例）或鳞状癌（26例），21例患者（23例）至少参加了一次随访，7例患者随访数据不完整治疗的完全缓解与第21天较小的肿瘤大小相关（P = 0.0143）， 63%（19/31）的症状部位出现症状缓解，未发现严重的晚期毒性。结论该缓解方案为非黑色素瘤皮肤癌患者提供了令人印象深刻的缓解率和有效的症状缓解(C) 2010年，the Royal College of Radiologists Published by Elsevier版权所有
Aims The primary objective of this study was to assess the rate of tumour response to the palliative radiotherapy regimen used at our centre (8 Gy/fraction on days 0 7 21) for non-melanoma skin cancer The secondary objective was to evaluate symptom palliationMaterials and methods A retrospective chart review identified patients treated with this palliative radiotherapy regimen from August 2003 to December 2008 Patient age gender tumour histology location size presenting symptoms and radiation treatment factors were recorded at baseline The tumour size and tumour-related symptoms were recorded at each fraction and follow-up visit The results were analysed on an intent to treat basisResults Twenty-eight patients received 31 courses of palliative radiation for basal cell (five) or squamous all (26) carcinoma of the skin Twenty-one patients with 23 tumours attended at least one follow-up visit and seven patients had Incomplete follow-up data At the time of last follow-up (median 17 weeks) the response rate was 58 1% (complete response 15/31 partial response 3/31) A complete response to treatment was correlated with a smaller tumour size at day 21 (P = 0 0143) Presenting symptoms were alleviated in 61 3% (19/31) of symptomatic sites No severe late toxicities were seenConclusions This palliative regimen offers impressive response rates and effective symptom palliation for patients with non-melanoma skin cancer (C) 2010 The Royal College of Radiologists Published by Elsevier Ltd All rights reserved