Werner's syndrome: a clinical-roentgen entity.
Werner's syndrome: a clinical-roentgen entity.
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维尔纳综合征：一种临床伦琴实体。
DOI：
10.1148/74.3.373
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发表时间：
1960
期刊：
影响因子：
19.7
通讯作者：
D. Zucker‐Franklin
中科院分区：
文献类型：
--
作者：
H. Jacobson;H. Rifkin;D. Zucker‐Franklin
1904年，Otto Werner(1)描述了一种名为“与硬皮病有关的白内障”的综合征，该综合征涉及一个有6个孩子的家庭中的两个兄弟和两个姐妹。30年后，奥本海默和库格尔发表了美国文献中第一个关于沃纳综合症的完整报告，就像在纽约市蒙特菲奥里医院的双胞胎兄弟观察到的那样。从那时起，记录的这种综合征的病例已经被描述(3-19例)，但其中只有2例有权威的尸检观察。从已发表的文献来看，沃纳综合征最好的描述是：这种疾病在男性和女性中发生的频率相等，并在青春期后不久显露出来。此时注意到各种干扰，包括四肢皮下组织和肌肉质量的丧失，手脚皮肤的进行性变化，过早脱发的头发变白，以及正常生长障碍。随着病情的发展，四肢变得..。
IN 1904, Otto Werner (1) described a syndrome called“cataract in connection with scleroderma" which involved 2 brothers and 2 sisters in a family of 6 children. Thirty years later, Oppenheimer and Kugel (2) published the first complete report of Werner's syndrome in the American literature, as observed in twin brothers at Montefiore Hospital in New York City. Since then, 64 documented cases of this syndrome have been described (3-19), but for only 2 of these, were there authoritative autopsy observations. From the published literature Werner's syndrome may best be described as follows: The disease occurs with equal frequency in both males and females and becomes manifest shortly after adolescence. A variety of disturbances are noted at this time, including loss of the subcutaneous tissues and muscle mass of the extremities, progressive changes in the skin of the hands and feet, graying of the hair with premature alopecia, and impairment of normal growth. As the condition progresses, the extremities become...