Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis:: Development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis:: Development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells
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DOI：
10.4049/jimmunol.171.11.5853
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发表时间：
2003-12-01
影响因子：
4.4
通讯作者：
Farrar, MA
中科院分区：
文献类型：
--
作者：
Burchill, MA;Goetz, CA;Farrar, MA
使用转基因小鼠表达的组成型活性版本的STAT 5 B，我们证明，STAT 5起着关键作用，在管理B细胞的发展和T细胞的稳态。STAT 5激活导致pro-B细胞增加10倍，而不是pro-T细胞。相反，STAT 5信号传导促进成熟的γ δ T细胞（增加6倍）和γ δ和NK T细胞（增加3至4倍）的扩增，但不促进成熟的B细胞的扩增。此外，STAT 5激活对CD 8（+）与CD 4（+）T细胞具有显著不同的作用，导致CD 8（+）记忆样T细胞和CD 4（+）CD 25（+）调节性T细胞的选择性扩增。这些结果表明，STAT 5的激活是初始和记忆CD 8（+）T细胞的IL-7/IL-15依赖性稳态增殖和CD 4（+）CD 25（+）调节性T细胞的IL-2依赖性发育的主要机制。
Using transgenic mice that express a constitutively active version of STAT5b, we demonstrate that STAT5 plays a key role in governing B cell development and T cell homeostasis. STAT5 activation leads to a 10-fold increase in pro-B, but not pro-T, cells. Conversely, STAT5 signaling promotes the expansion of mature alphabetaT cells (6-fold increase) and gammadelta and NK T cells (3- to 4-fold increase), but not of mature B cells. In addition, STAT5 activation has dramatically divergent effects on CD8(+) vs CD4(+) T cells, leading to the selective expansion of CD8(+) memory-like T cells and CD4(+)CD25(+) regulatory T cells. These results establish that activation of STAT5 is the primary mechanism underlying both IL-7/IL-15-dependent homeostatic proliferation of naive and memory CD8(+) T cells and IL-2-dependent development of CD4(+)CD25(+) regulatory T cells.