Variants in DENND1A and LHCGR are associated with endometrioid adenocarcinoma
Variants in DENND1A and LHCGR are associated with endometrioid adenocarcinoma
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DENND1A 和 LHCGR 的变异与子宫内膜样腺癌相关。
DOI：
10.1016/j.ygyno.2012.08.007
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发表时间：
2012-11-01
影响因子：
4.7
通讯作者：
Chen, Zi-Jiang
中科院分区：
文献类型：
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作者：
Wang, Zhenyan;Li, Tao;Chen, Zi-Jiang
Objective.本研究旨在探讨多囊卵巢综合征（PCOS）相关的单核苷酸多态性（SNPs）rs13405728（LHCGR基因）、rs13429458（THADA基因）和rs2479106（DEND1A基因）与子宫内膜癌的关系。我们进行了一项病例对照研究，包括96名汉族子宫内膜癌妇女和192名健康对照。通过聚合酶链反应（PCR）和直接测序对SNPs rs13405728、rs13429458和rs2479106进行基因分型。采用非条件Logistic回归模型对体重指数（BMI）和年龄的影响进行评估，并对潜在的混杂因素进行校正。rs2479106和rs13405728等位基因频率在子宫内膜癌组和对照组之间差异有统计学意义（P < 0.05），其中在子宫内膜样腺癌组中差异尤为显著。基因分型结果显示，rs2479106等位基因G和rs13405728等位基因A可能与乳腺癌相关。我们的研究结果表明，SNPs rs2479106基因DEND1A和rs13405728基因LHCGR与卵巢样腺癌相关。2012 Elsevier Inc. All rights reserved.
Objective. The aim of this study was to explore the polycystic ovary syndrome (PCOS) related single nucleotide polymorphisms (SNPs) rs13405728 (in gene LHCGR), rs13429458 (in gene THADA) and rs2479106 (in gene DENND1A) in women with endometrial carcinoma.Methods. We conducted a case-control study comprising 96 Han Chinese women with endometrial carcinoma, and 192 healthy controls. SNPs rs13405728, rs13429458 and rs2479106 were genotyped by polymerase chain reaction (PCR) and direct sequencing. The effects of body mass index (BMI) and age were evaluated using an unconditional logistic regression model adjusted for potential confounders.Results. The allele frequencies of SNPs rs2479106 and rs13405728 were significantly different (P < 0.05) between endometrial carcinoma group and control group, and the difference was especially significant in the subgroup of endometrioid adenocarcinoma. Genotyping analysis showed that allele G in rs2479106 and allele A in rs13405728 could confer risk to endometrioid adenocarcinoma.Conclusions. Our results suggest that SNPs rs2479106 in gene DENND1A and rs13405728 in gene LHCGR are associated with endometrioid adenocarcinoma. 2012 Elsevier Inc. All rights reserved.