The effect of intra-articular hyaluronic acid treatment on gait velocity in older knee osteoarthritis patients: A randomized, controlled study
The effect of intra-articular hyaluronic acid treatment on gait velocity in older knee osteoarthritis patients: A randomized, controlled study
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DOI：
10.1016/j.archger.2011.11.007
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发表时间：
2012-09-01
影响因子：
4
通讯作者：
Petrella, Robert J.
中科院分区：
文献类型：
--
作者：
DeCaria, Joseph E.;Montero-Odasso, Manuel;Petrella, Robert J.
目的：探讨关节内透明质酸（HA）对老年膝关节骨性关节炎（OA）患者步态速度、疼痛和功能的影响。材料和方法：30例膝关节OA患者（kellgreen - lawrence II-III）[72.44（+/- 6.11）岁]使用Microsoft Excel中的“RANDBETWEEN”函数随机化，接受每周3次注射HA （20 mg/ml HA 2 ml）或安慰剂(P) (0.001 mg/ml HA 1.2 ml)，每组15名参与者。患者和评估人员对治疗一无所知。采用GAITRite (R)系统测量自选步态和快速步态速度。采用Western Ontario McMaster骨关节炎OA指数（WOMAC OA指数）测量膝关节疼痛、僵硬度和身体功能。治疗后1周、3、6个月的数据采用重复测量方差分析。结果：HA组显著提高了自选和快速步态速度，P组仅显著提高了自选步态速度。自我选择步态速度的平均改善[均值（SD）；95% CI [1.25 (52.4) cm/s；-18.38;20.88]步态速度快[7.16 (71.75)cm/s；-19.72;34.04]组间差异无统计学意义。HA组WOMAC疼痛评分的改善明显大于P组[-2.47 (6.39)]；-4.86;-0.08]，而刚度改进[-0.87 (2.42)；-1.77;0.04]和生理机能[-7.23 (19.77)]；-14.63;0.16]得分则没有。结论：与安慰剂相比，HA对老年膝关节OA患者步态速度的总体影响不显著。在更大的老年膝关节OA患者样本中，应进一步研究HA治疗后快速步态速度改善的初步结果，以及跌倒的发生率。ClinicalTrials.gov ID: NCT00778076。2011爱思唯尔爱尔兰有限公司版权所有。
Purpose: To determine the effect of intra-articular hyaluronic acid (HA) on gait velocity, pain, and function, in older knee osteoarthritis (OA) patients. Materials and methods: Thirty knee OA patients (Kellgren-Lawrence II-III) [72.44 (+/- 6.11)years old] were randomized, using the 'RANDBETWEEN' function in Microsoft Excel, to receive three weekly injections of HA (2 ml of 20 mg/ml HA), or placebo (P) (1.2 ml of 0.001 mg/ml HA), with fifteen participants per group. Patients and assessors were blind to treatment. Self-selected and fast gait velocities were measured with the GAITRite (R) system. Knee pain, stiffness, and physical function were measured with the Western Ontario McMaster Osteoarthritis OA index (WOMAC OA index). Data from 1 week, 3 and 6 months post-treatment were analyzed using repeated measures ANOVA. Results: The HA group significantly improved self-selected and fast gait velocity, while the P group only significantly improved self-selected gait velocity. Mean improvements in self-selected gait velocity [Mean (SD); 95% CI] [1.25 (52.4) cm/s; -18.38; 20.88] and fast gait velocity [7.16 (71.75) cm/s; -19.72; 34.04] were not significantly different between groups. Improvements in WOMAC pain scores were significantly greater in the HA group than the P group [-2.47 (6.39); -4.86; -0.08], while improvements in stiffness [-0.87 (2.42); -1.77; 0.04] and physical function [-7.23 (19.77); -14.63; 0.16] scores were not. Conclusions: The overall effect of HA on gait velocity in older knee OA patients was not significant compared to placebo. The preliminary results of improved fast gait velocity following HA treatment should be investigated further, along with the incidence of falls, in a larger sample of older knee OA patients. ClinicalTrials.gov ID: NCT00778076. (C) 2011 Elsevier Ireland Ltd. All rights reserved.