Hyaluronan and Layilin Mediate Loss of Airway Epithelial Barrier Function Induced by Cigarette Smoke by Decreasing E-cadherin
Hyaluronan and Layilin Mediate Loss of Airway Epithelial Barrier Function Induced by Cigarette Smoke by Decreasing E-cadherin
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DOI：
10.1074/jbc.m112.387795
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发表时间：
2012-12-07
影响因子：
4.8
通讯作者：
Monzon, Maria E.
中科院分区：
文献类型：
--
作者：
Forteza, Rosanna Malbran;Casalino-Matsuda, S. Marina;Monzon, Maria E.
香烟烟雾(CIGs)暴露与支气管上皮通透性增加和屏障功能受损有关。原代培养的正常人支气管上皮细胞暴露于CIG后，E-钙粘附素表达降低，跨上皮电阻值降低。这些效应是由透明质酸(HA)介导的，因为抑制其与4-甲基伞形酮的合成阻止了这些效应，并且暴露于HA片段
Cigarette smoke (CigS) exposure is associated with increased bronchial epithelial permeability and impaired barrier function. Primary cultures of normal human bronchial epithelial cells exposed to CigS exhibit decreased E-cadherin expression and reduced transepithelial electrical resistance. These effects were mediated by hyaluronan (HA) because inhibition of its synthesis with 4-methylumbelliferone prevented these effects, and exposure to HA fragments of