Impact of adjuvants on CD4+ T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial
Impact of adjuvants on CD4+ T cell and B cell responses to a protein antigen vaccine: Results from a phase II, randomized, multicenter trial
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DOI：
10.1016/j.clim.2016.05.007
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发表时间：
2016-08-01
影响因子：
8.6
通讯作者：
Van Mechelen, Marcelle
中科院分区：
文献类型：
--
作者：
Leroux-Roels, Geert;Marchant, Arnaud;Van Mechelen, Marcelle
比较不同佐剂与模型抗原（HBsAg）联合的免疫原性和安全性。未感染 HBV 的健康成人在第 0 天和第 30 天随机接受明矾或佐剂系统 AS01B、AS01E、AS03A 或 AS04 佐剂的 HBs。第 2 次给药后 14 天，不同佐剂诱导出 HBs 特异性 CD4+ T 细胞的频率不同，但具有相似的多功能性特征，其中 AS01B 和 AS01E 组的频率明显高于其他组。第 2 次给药后 30 天，AS01B、AS01E 和 AS03A 中的抗体浓度显着高于其他组。 HBs 特异性 CD4+ T 细胞和抗体反应之间观察到有限的相关性。注射部位疼痛是最常见的局部症状，并且在 AS 组中比明矾组中更常见。用相同抗原配制的不同佐剂在健康的幼稚成人中诱导不同的适应性免疫反应和反应原性模式。 (C) 2016 年作者。由爱思唯尔公司出版
Immunogenicity and safety of different adjuvants combined with a model antigen (HBsAg) were compared. Healthy HBV-naive adults were randomized to receive HBs adjuvanted with alum or Adjuvant Systems AS01B, AS01E, AS03A or AS04 at Days 0 and 30. Different frequencies of HBs-specific CD4+ T cells 14 days post dose 2 but similar polyfunctionality profiles were induced by the different adjuvants with frequencies significantly higher in the AS01B and AS01E groups than in the other groups. Antibody concentrations 30 days post-dose 2 were significantly higher in AS01B, AS01E and AS03A than in other groups. Limited correlations were observed between HBs-specific CD4+ T cell and antibody responses. Injection site pain was the most common solicited local symptom and was more frequent in AS groups than in alum group. Different adjuvants formulated with the same antigen induced different adaptive immune responses and reactogenicity patterns in healthy naive adults. (C) 2016 The Authors. Published by Elsevier Inc.