Acoustic radiation force and optical spectroscopy for assessing tumor vessel normalization during anti-angiogenic therapy.
Acoustic radiation force and optical spectroscopy for assessing tumor vessel normalization during anti-angiogenic therapy.
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声辐射力和光谱学用于评估抗血管生成治疗期间肿瘤血管正常化。
DOI：
10.1109/iembs.2009.5333814
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Yu,Yan
中科院分区：
文献类型：
--
作者：
Yan,Kaiguo;Wachsberger,Phyllis;Yu,Yan
分子氧是放射治疗中最著名的辐射损伤介质。本文探讨了利用抗血管生成疗法增强肿瘤氧合以提高放射敏感性的技术。本文提出了一种无创监测技术——声辐射力诱导光谱学，用于跟踪抗血管生成治疗过程中肿瘤氧的变化。以右后肢移植人U87胶质母细胞瘤（ATCC）的雄性NCR-NUM裸鼠为研究对象。使用药物AZD2171（阿斯利康）的抗血管生成方案被发现能够在药物治疗的第一周改善组织氧合。光谱学技术被证明能够跟踪抗血管生成治疗期间肿瘤氧合的变化，并通过直接测量pO2进行验证。通过在放射治疗前使用抗血管生成疗法来改善肿瘤氧合，组织氧合可能会以一种有利于放射治疗的方式改变。
Molecular oxygen is the best known mediator of radiation damage during radiation therapy. This paper investigates techniques for enhancing tumor oxygenation by use of anti-angiogenic therapy for better radiosensitivity. A noninvasive monitoring technique, Acoustic radiation force (ARF)-induced optical spectroscopy, was proposed in this paper to track tumor oxygen changes during anti-angiogenic therapy. Male NCR-NUM nude mice bearing human U87 glioblastoma (ATCC) xenografts on the right hind limb were used for the study. An anti-angiogenic regimen using the drug AZD2171 (AsraZeneca) was found capable of improving tissue oxygenation during the first week of drug treatment. The optical spectroscopy technique was shown to be able to track tumor oxygenation changes during anti-angiogenic therapy, as verified by direct pO2 measurement. By using anti-angiogenic therapy to improve tumor oxygenation prior to radiotherapy, tissue oxygenation may be altered in a way that favors radiation therapy.