Gamma Interferon Release Assay for Monitoring of Treatment Response for Active Tuberculosis: an Explosion in the Spaghetti Factory
Gamma Interferon Release Assay for Monitoring of Treatment Response for Active Tuberculosis: an Explosion in the Spaghetti Factory
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DOI：
10.1128/jcm.02278-12
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发表时间：
2013-02-01
影响因子：
9.4
通讯作者：
Menzies, Dick
中科院分区：
文献类型：
--
作者：
Denkinger, Claudia M.;Pai, Madhukar;Menzies, Dick
很少有研究将干扰素（γ干扰素）释放试验（IGRA）的结果与已知的结核病（TB）治疗反应标志物相关联。我们报告了对149名活动性结核病患者进行的系列QuantiFERON-TB金试管检测（QFT）测试的结果，并将结果与涂片和培养转化相关联。我们表明，QFT结果并没有提供结核病治疗监测的价值。
Few studies have correlated the results of interferon (gamma interferon) release assays (IGRAs) with known markers of tuberculosis (TB) treatment response. We report the results of serial QuantiFERON-TB gold in-tube assay (QFT) testing on 149 patients with active tuberculosis and correlate the results with smear and culture conversion. We show that QFT results do not offer much value for treatment monitoring of TB disease.