Carotid bodies are required for ventilatory acclimatization to chronic hypoxia.
Carotid bodies are required for ventilatory acclimatization to chronic hypoxia.
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颈动脉体对于通气适应慢性缺氧是必需的。
DOI：
10.1152/jappl.1986.60.3.1003
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Dempsey,JA
中科院分区：
文献类型：
--
作者：
Smith,CA;Bisgard,GE;Nielsen,AM;Daristotle,L;Kressin,NA;Forster,HV;Dempsey,JA
我们比较了正常山羊和颈动脉体部失神经(CBD)山羊在长达7天的低血压下对中等[动脉血氧分压；(PaO2)约44Torr]和重度(PaO2约33Torr)多个时间点的呼吸反应。在正常组中，中度和重度低氧血症(约-7和-11 Torr)的动脉血二氧化碳分压(PaCO2)均有显着的时间依赖性下降，这种下降在低氧血症8小时时基本完成，并始终保持。在长期低氧的完整动物中，急性恢复常氧使PaCO2在2小时内呈时间依赖性的增加，但相对于海平面控制，低二氧化碳持续存在。动脉血[HCO3-]和[H+]降低，[Cl-]升高，且与低碳酸血症发生的时程和程度一致。慢性CBD本身导致持续的部分代偿性呼吸性酸中毒，PaCO2上升6Torr，碱过量上升3mEq/l，[Cl-]下降1mEq/l，PHA下降0.01个单位。在暴露于与完整组相同水平的动脉低氧血症期间。在中度或重度低氧血症期间，CBD动物的PaCO2、[H+]a或[HCO3-]a在任何时候都没有显著变化。血浆[C1-]在中度缺氧时始终保持在正常范围内，重度缺氧时升高。在少数情况下观察到了一些低碳酸血症，但这是高度不一致的，总是不到完整山羊观察到的三分之一。与完整的山羊相比，慢性缺氧的CBD山羊在急性恢复常氧时总是会引起过度换气。
We have compared the ventilatory responses of intact and carotid body-denervated (CBD) goats to moderate [partial pressure of O2 in arterial blood; (Pao2) approximately 44 Torr] and severe (Pao2 approximately 33 Torr) many time points for up to 7 days of hypobaria. In the intact group there were significant time-dependent decreases in partial pressure of CO2 in arterial blood (PaCO2) in both moderate and severe hypoxemia (approximately-7 and -11 Torr) that were largely complete by 8 h of hypoxemia and maintained throughout. Acute restoration of normoxia in chronically hypoxic intact animals produced time-dependent increases in Paco2 over 2 h, but hypocapnia persisted relative to sea-level control. Arterial plasma [HCO3-] and [H+] decreased, and [Cl-] increased with a time course and magnitude consistent with developing hypocapnia. Chronic CBD, per se, resulted in a sustained, partially compensated respiratory acidosis, as PaCO2 rose 6 Torr and base excess rose 3 mEq/1, [Cl-] fell 1 mEq/1, and pHa fell 0.01 units. During exposure to identical levels of arterial hypoxemia as in the intact group. CBD animals showed no significant changes in PaCO2, [H+]a, or [HCO3-]a at any time during moderate or severe hypoxemia. Plasma [C1-] remained within the normal range throughout exposure to moderate hypoxia and increased in severe hypoxia. In a few instances some hypocapnia was observed, but this was highly inconsistent and was always less than one-third of that observed in intact goats. In contrast to intact goats, acute restorations of normoxia in the chronically hypoxic CBD goats always caused hyperventilation.(ABSTRACT TRUNCATED AT 250 WORDS)