THE INFLUENCE OF ESTROGEN ON NIGROSTRIATAL DOPAMINE ACTIVITY - BEHAVIORAL AND NEUROCHEMICAL EVIDENCE FOR BOTH PRE-NAPTIC AND POSTSYNAPTIC COMPONENTS
THE INFLUENCE OF ESTROGEN ON NIGROSTRIATAL DOPAMINE ACTIVITY - BEHAVIORAL AND NEUROCHEMICAL EVIDENCE FOR BOTH PRE-NAPTIC AND POSTSYNAPTIC COMPONENTS
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DOI：
10.1016/0166-4328(86)90044-6
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发表时间：
1986-01-01
影响因子：
2.7
通讯作者：
BEER, ME
中科院分区：
文献类型：
--
作者：
BECKER, JB;BEER, ME
本文报道了雌激素对黑质纹状体多巴胺（DA）系统影响的3项实验结果。在两个实验中，用单侧6-羟多巴胺损伤的黑质大鼠研究了激素操作对安非他明（AMPH）诱导的旋转行为的影响。结果表明：(1)发情期雌性大鼠比去卵巢（OVX）大鼠产仔率高；(2)雌激素治疗（5 .mu）。雌激素治疗后4小时和4天，OVX大鼠的amph诱导的旋转行为增强。在干预期间，在停止雌激素治疗后24小时，对照组和激素治疗的动物没有差异。在第三个实验中，我们观察了雌激素处理对纹状体组织切片内源性DA释放的影响。与OVX对照组相比，雌激素在末次治疗后4小时增强了amph刺激的纹状体DA释放。然而，雌激素治疗后24小时和4天，DA释放恢复到对照水平。这表明雌激素对纹状体DA释放有直接的增强作用，这可能是雌激素治疗后4小时对AMPH行为反应增加的原因。先前证明的突触后纹状体DA受体的增加可能是雌激素治疗后4天amph诱导的旋转行为第二次增加的原因。
The results of 3 experiments examining the influence of estrogen on the nigrostriatal dopamine (DA) system are reported. In two experiments the influence of hormonal manipulations on amphetamine (AMPH)-induced rotational behavior was investigated using rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. It was found that: (1) female rats in estrus make more ratations than ovariectomized (OVX) rats; and (2) estrogen treatment (5 .mu.g estradiol benzoate, daily for 4 days) in OVX rats enhances AMPH-induced rotational behavior 4 h and 4 days after estrogen treatment. During the intervening period, at 24 h after cessation of estrogen treatment, control and hormone-treated animals did not differ. In a third experiment, the effect of estrogen treatment on the release of endogenous DA from striatal tissue slices in superfusion was examined. Estrogen enhanced AMPH-stimulated striatal DA release 4 h after the last treatment relative to OVX controls. However, 24 h and 4 days after estrogen treatment DA release had returned to control levels. It is suggested that estrogen has an immediate potentiating effect on striatal DA release, and this may be responsible for the increased behavioral response to AMPH 4 h after estrogen treatment. The previously demonstrated increase in postsynaptic striatal DA receptors may be responsible for the second increase in AMPH-induced rotational behavior, that occurs 4 days after estrogen treatment.