Presumed inhibitory neurons in the macaque inferior temporal cortex: visual response properties and functional interactions with adjacent neurons.
Presumed inhibitory neurons in the macaque inferior temporal cortex: visual response properties and functional interactions with adjacent neurons.
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DOI：
10.1152/jn.01267.2003
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发表时间：
2004-06
影响因子：
2.5
通讯作者：
H. Tamura;H. Kaneko;K. Kawasaki;I. Fujita
中科院分区：
文献类型：
--
作者：
H. Tamura;H. Kaneko;K. Kawasaki;I. Fujita
猴子下颞叶皮层TE区的神经元对特定物体的图像或其特有的视觉特征有选择性地作出反应。然而，刺激选择性产生的机制在很大程度上是未知的。本研究通过考察TE神经元的视觉反应特性和与邻近目标神经元的相互作用，探讨了TE神经元在这一过程中的作用。我们对麻醉猕猴的成对相邻神经元同时记录的脉冲序列进行了相互关联分析。如果神经元的活动先于同伴的活动减少，则被认为是抑制性神经元。兴奋性神经元也被确定为兴奋性连锁的源神经元，交叉相关图中0-ms bin的尖峰移位证明了这一点。在我们的刺激集中，大多数抑制神经元对多种视觉刺激有反应，这些刺激集由几十个几何图形和物体照片组成，具有明显的刺激偏好。平均而言，10%的刺激增加了抑制性神经元的放电率。兴奋性和抑制性神经元均表现出相似程度的刺激选择性。尽管抑制性神经元偶尔会与其目标神经元共享最喜欢的刺激，但与具有共同输入和/或兴奋性连接的相邻神经元相比，具有抑制性连接的相邻神经元之间的总体刺激偏好不那么相似。这些结果表明，TE区的抑制性神经元被选择性激活，并对邻近神经元施加刺激特异性抑制，有助于TE神经元刺激选择性的形成。
Neurons in area TE of the monkey inferior temporal cortex respond selectively to images of particular objects or their characteristic visual features. The mechanism of generation of the stimulus selectivity, however, is largely unknown. This study addresses the role of inhibitory TE neurons in this process by examining their visual response properties and interactions with adjacent target neurons. We applied cross-correlation analysis to spike trains simultaneously recorded from pairs of adjacent neurons in anesthetized macaques. Neurons whose activity preceded a decrease in activity from their partner were presumed to be inhibitory neurons. Excitatory neurons were also identified as the source neuron of excitatory linkage as evidenced by a sharp peak displaced from the 0-ms bin in cross-correlograms. Most inhibitory neurons responded to a variety of visual stimuli in our stimulus set, which consisted of several dozen geometrical figures and photographs of objects, with a clear stimulus preference. On average, 10% of the stimuli increased firing rates of the inhibitory neurons. Both excitatory and inhibitory neurons exhibited a similar degree of stimulus selectivity. Although inhibitory neurons occasionally shared the most preferred stimuli with their target neurons, overall stimulus preferences were less similar between adjacent neurons with inhibitory linkages than adjacent neurons with common inputs and/or excitatory linkages. These results suggest that inhibitory neurons in area TE are activated selectively and exert stimulus-specific inhibition on adjacent neurons, contributing to shaping of stimulus selectivity of TE neurons.