Anticipatory activity in the human thalamus is predictive of reaction times
Anticipatory activity in the human thalamus is predictive of reaction times
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DOI：
10.1016/j.neuroscience.2008.07.005
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发表时间：
2008-09-09
期刊：
影响因子：
3.3
通讯作者：
Klostermann, F.
中科院分区：
文献类型：
--
作者：
Nikulin, V. V.;Marzinzik, F.;Klostermann, F.
对环境刺激的快速反应是一种基本的行为能力。一个人的反应速度已知是由皮质区域预先决定的，但皮质下结构是否也参与定义运动快速性仍有待研究。由于丘脑先前被认为与行为控制有关，我们测试了这一水平的神经元活动是否也可以预测即将到来的运动的反应时间。为此，我们同时记录了接受丘脑深部脑刺激的患者的头皮和丘脑腹侧中间核(VIM)的脑电活动。基于对GO/NOGO任务的逐次试验分析，我们证明了在即将到来的GO刺激传递之前，大脑皮层和丘脑神经元的活动与反应时间相关。这一结果超越了丘脑活动与运动能力相关但可能保持不变的证明。相反，它表明我们对环境刺激的反应潜伏期不仅与大脑皮层运动前状态有关，还与预期的丘脑活动相关。(C)2008年IBRO。爱思唯尔有限公司出版。保留所有权利。
Responding to environmental stimuli in a fast manner is a fundamental behavioral capacity. The pace at which one responds is known to be predetermined by cortical areas, but it remains to be shown if subcortical structures also take part in defining motor swiftness. As the thalamus has previously been implicated in behavioral control, we tested if neuronal activity at this level could also predict the reaction time of upcoming movements. To this end we simultaneously recorded electrical brain activity from the scalp and the ventral intermediate nucleus (VIM) of the thalamus in patients undergoing thalamic deep brain stimulation. Based on trial-to-trial analysis of a Go/NoGo task, we demonstrate that both cortical and thalamic neuronal activity prior to the delivery of upcoming Go stimulus correlates with the reaction time. This result goes beyond the demonstration of thalamic activity being associated with but potentially staying invariant to motor performance. In contrast, it indicates that the latencies at which we respond to environmental stimuli are not exclusively related to cortical pre-movement states but are also correlated with anticipatory thalamic activity. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.