High performance of a chiral diene-rhodium catalyst for the asymmetric 1,4-addition of arylboroxines to α,β-unsaturated ketones
High performance of a chiral diene-rhodium catalyst for the asymmetric 1,4-addition of arylboroxines to α,β-unsaturated ketones
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DOI：
10.1021/ol052756e
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发表时间：
2006-01-19
期刊：
影响因子：
5.2
通讯作者：
Hayashi, T
中科院分区：
文献类型：
--
作者：
Chen, FX;Kina, A;Hayashi, T
与 (SS)-2,5-二苄基双环[2.2.2]八-2,5-二烯 (Bn-bod*) 配位的铑配合物在芳基环硼氧烷与环状 α,β-不饱和酮的不对称 1,4-加成反应中表现出高催化活性和高对映选择性，0.005-0.01 mol % 的催化剂可提供高收率的加成产物，且低于 94% ee。催化剂的周转频率高达1.4×10(4)h(-1)。
A rhodium complex coordinated with (SS)-2,5-dibenzylbicyclo[2.2.2]octa-2,5-diene (Bn-bod*) showed high catalytic activity and high entantioselectivity in the asymmetric 1,4-addition of arylboroxines to cyclic alpha,beta-unsaturated ketones, 0.005-0.01 mol % of the catalyst giving high yields of the addition products with not lower than 94% ee. The turnover frequency of the catalyst is up to 1.4 x 10(4) h(-1).