"Complementing" toll signaling.
"Complementing" toll signaling.
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DOI：
10.1126/scisignal.3120pe15
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发表时间：
2010
影响因子：
7.3
通讯作者：
Kagan,JonathanC
中科院分区：
文献类型：
--
作者：
Kagan,JonathanC
信号转导的研究通常集中在解剖细胞对激活单一受体的单一刺激的反应。这些类型的研究为我们目前对信号的理解奠定了基础，也为今天教科书中无数含箭头的模型的产生奠定了基础。在大多数模型中隐含的是这样的建议，即从激活的受体发出的箭头代表总是被给定受体激活的核心信号通路，从而导致核心细胞反应。然而，在自然界中，很可能没有信号通路是孤立激活的。相反，细胞通常同时对多种刺激做出反应，并且细胞反应可能是几种信号传导途径的结果。一项新的研究试图在体外模拟这种情况，并揭示当巨噬细胞遇到细菌时，两种信号转导途径以一种深刻改变细胞对感染反应的方式相互作用。
Studies of signal transduction are often focused on dissecting the cellular response to a single stimulus that activates a single receptor. These types of studies laid the foundation for our current understanding of signaling, as well as the generation of countless arrow-containing models in today’s textbooks. Implicit in most models is the suggestion that the arrows emanating from an activated receptor represent the core signaling pathways that are always activated by a given receptor, thus leading to a core cellular response. In nature, however, it is likely that no signaling pathway is activated in isolation. Rather, cells often respond to multiple stimuli simultaneously, and the cellular response may be the result of several signaling pathways. A new study attempts to model such conditions in vitro and reveals that when macrophages encounter bacteria, two signal transduction pathways interact in a way that profoundly alters the cellular response to infection.